• Je něco špatně v tomto záznamu ?

Conductivity of natural and modified DNA measured by scanning tunneling microscopy. The effect of sequence, charge and stacking

I Kratochvilova, K Kral, M Buncek, A Viskova, S Nespurek, A Kochalska, T Todorciuc, M Weiter, B Schneider

. 2008 ; 138 (1-2) : 3-10.

Jazyk angličtina Země Nizozemsko

Perzistentní odkaz   https://www.medvik.cz/link/bmc11004753

The conductivity of DNA covalently bonded to a gold surface was studied by means of the STM technique. Various single- and double-stranded 32-nucleotide-long DNA sequences were measured under ambient conditions so as to provide a better understanding of the complex process of charge-carrier transport in natural as well as chemically modified DNA molecules. The investigations focused on the role of several features of DNA structure, namely the role of the negative charge at the backbone phosphate group and the related complex effects of counterions, and of the stacking interactions between the bases in Watson-Crick and other types of base pairs. The measurements have indicated that the best conductor is DNA in its biologically most relevant double-stranded form with Watson-Crick base pairs and charged phosphates equilibrated with counterions and water. All the studied modifications, including DNA with non-Watson-Crick base pairs, the abasic form, and especially the form with phosphate charges eliminated by chemical modifications, lower the conductivity of natural DNA.

Citace poskytuje Crossref.org

000      
02807naa 2200457 a 4500
001      
bmc11004753
003      
CZ-PrNML
005      
20111210202728.0
008      
110309s2008 ne e eng||
009      
AR
024    __
$a 10.1016/j.bpc.2008.08.005 $2 doi
035    __
$a (PubMed)18801607
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Kratochvílová, Irena. $7 _AN059186
245    10
$a Conductivity of natural and modified DNA measured by scanning tunneling microscopy. The effect of sequence, charge and stacking / $c I Kratochvilova, K Kral, M Buncek, A Viskova, S Nespurek, A Kochalska, T Todorciuc, M Weiter, B Schneider
314    __
$a Institute of Physics, ASCR, v.v.i., Na Slovance 2, CZ-18221 Prague, Czech Republic. krat@fzu.cz
520    9_
$a The conductivity of DNA covalently bonded to a gold surface was studied by means of the STM technique. Various single- and double-stranded 32-nucleotide-long DNA sequences were measured under ambient conditions so as to provide a better understanding of the complex process of charge-carrier transport in natural as well as chemically modified DNA molecules. The investigations focused on the role of several features of DNA structure, namely the role of the negative charge at the backbone phosphate group and the related complex effects of counterions, and of the stacking interactions between the bases in Watson-Crick and other types of base pairs. The measurements have indicated that the best conductor is DNA in its biologically most relevant double-stranded form with Watson-Crick base pairs and charged phosphates equilibrated with counterions and water. All the studied modifications, including DNA with non-Watson-Crick base pairs, the abasic form, and especially the form with phosphate charges eliminated by chemical modifications, lower the conductivity of natural DNA.
650    _2
$a párování bází $7 D020029
650    _2
$a sekvence nukleotidů $7 D001483
650    _2
$a DNA $x chemie $x metabolismus $7 D004247
650    _2
$a jednovláknová DNA $x chemie $7 D004277
650    _2
$a elektrická vodivost $7 D004553
650    _2
$a zlato $x chemie $7 D006046
650    _2
$a vodíková vazba $7 D006860
650    _2
$a rastrovací tunelová mikroskopie $7 D016252
650    _2
$a oligodeoxyribonukleotidy $x chemie $x metabolismus $7 D009838
650    _2
$a fosfáty $x chemie $x metabolismus $7 D010710
650    _2
$a financování organizované $7 D005381
700    1_
$a Král, Karel. $7 _AN059187
700    1_
$a Bunček, Martin, $d 1975- $7 mzk2006348916
700    1_
$a Víšková, Alena. $7 _AN059188
700    1_
$a Nešpůrek, Stanislav. $7 _AN059189
700    1_
$a Kochalská, Anna. $7 _AN059190
700    1_
$a Todorciuc, Tatiana
700    1_
$a Weiter, Martin. $7 _AN053510
700    1_
$a Schneider, Bohdan, $d 1927- $7 jn20000402190
773    0_
$t Biophysical Chemistry $w def $g Roč. 138, č. 1-2 (2008), s. 3-10
910    __
$a ABA008 $b x $y 1
990    __
$a 20110414093642 $b ABA008
991    __
$a 20110414093642 $b ABA008
999    __
$a ok $b bmc $g 832131 $s 696791
BAS    __
$a 3
BMC    __
$a 2008 $b 138 $c 1-2 $d 3-10 $m Biophysical chemistry $n Biophys Chem $x MED00000773
LZP    __
$a 2011-4B/vtme

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé