• Je něco špatně v tomto záznamu ?

Salicylanilide esters of N-protected amino acids as novel antimicrobial agents

A Imramovsky, J Vinsova, JM Ferriz, V Buchta, J Jampilek

. 2009 ; 19 (2) : 348-351.

Jazyk angličtina Země Velká Británie

Perzistentní odkaz   https://www.medvik.cz/link/bmc11006134
E-zdroje

NLK ScienceDirect (archiv) od 1993-01-01 do 2009-12-31

A series of novel, highly antimicrobial salicylanilide esters of N-protected amino acids were synthesized and characterized. Their in vitro antimicrobial activity against eight fungal strains and Mycobacterium tuberculosis was determined. The compounds had the highest level of activity against Aspergillus fumigatus, Absidia corymbifera and Trichophyton mentagrophytes, and these levels were higher than that of the standard drug fluconazole. In addition, three compounds showed interesting antituberculosis activity, with inhibition ranging from 89% to 99%. (S)-4-Chloro-2-(4-trifluoromethylphenylcarbamoyl)-phenyl 2-benzyloxy-carbonylamino-propionate had the highest level of both antifungal and antimycobacterial activity. The structure-activity relationships of the new compounds are discussed.

000      
02424naa 2200385 a 4500
001      
bmc11006134
003      
CZ-PrNML
005      
20121114125901.0
008      
110331s2009 xxk e eng||
009      
AR
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Imramovský, Aleš $7 xx0118877
245    10
$a Salicylanilide esters of N-protected amino acids as novel antimicrobial agents / $c A Imramovsky, J Vinsova, JM Ferriz, V Buchta, J Jampilek
314    __
$a Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. ales.imramovsky@faf.cuni.cz
520    9_
$a A series of novel, highly antimicrobial salicylanilide esters of N-protected amino acids were synthesized and characterized. Their in vitro antimicrobial activity against eight fungal strains and Mycobacterium tuberculosis was determined. The compounds had the highest level of activity against Aspergillus fumigatus, Absidia corymbifera and Trichophyton mentagrophytes, and these levels were higher than that of the standard drug fluconazole. In addition, three compounds showed interesting antituberculosis activity, with inhibition ranging from 89% to 99%. (S)-4-Chloro-2-(4-trifluoromethylphenylcarbamoyl)-phenyl 2-benzyloxy-carbonylamino-propionate had the highest level of both antifungal and antimycobacterial activity. The structure-activity relationships of the new compounds are discussed.
650    _2
$a Absidia $x účinky léků $7 D020095
650    _2
$a aminokyseliny $x chemie $7 D000596
650    _2
$a antiinfekční látky $x farmakologie $x chemie $7 D000890
650    _2
$a Aspergillus fumigatus $x účinky léků $7 D001232
650    _2
$a estery $7 D004952
650    _2
$a mikrobiální testy citlivosti $7 D008826
650    _2
$a Mycobacterium tuberculosis $x účinky léků $7 D009169
650    _2
$a salicylanilidy $x farmakologie $x chemie $7 D012458
650    _2
$a Trichophyton $x účinky léků $7 D014249
650    _2
$a financování organizované $7 D005381
700    1_
$a Vinšová, Jarmila, $d 1951- $7 nlk19990073991
700    1_
$a Ferriz, Juana Monreal
700    1_
$a Buchta, Vladimír, $d 1960- $7 mzk2002156768
700    1_
$a Jampílek, Josef $7 xx0027075
773    0_
$t Bioorganic & Medicinal Chemistry Letters $w MED00000770 $g Roč. 19, č. 2 (2009), s. 348-351
910    __
$a ABA008 $b x $y 2
990    __
$a 20110414112851 $b ABA008
991    __
$a 20121114125917 $b ABA008
999    __
$a ok $b bmc $g 833752 $s 698225
BAS    __
$a 3
BMC    __
$a 2009 $b 19 $c 2 $d 348-351 $m Bioorganic & medicinal chemistry letters $n Bioorg Med Chem Lett $x MED00000770
LZP    __
$a 2011-1B09/dkme

Najít záznam