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A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment
P Hamal, J Ostransky, M Dendis, R Horvath, F Ruzicka, V Buchta, M Vejsova, P Sauer, P Hejnar, V Raclavsky
Jazyk angličtina Země Velká Británie
Typ dokumentu kazuistiky
Grantová podpora
NR8365
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Část
Zdroj
NLK
Medline Complete (EBSCOhost)
od 2003-02-01 do Před 18 měsíci
- MeSH
- antifungální látky farmakologie MeSH
- azoly farmakologie MeSH
- biofilmy MeSH
- dospělí MeSH
- endokarditida farmakoterapie mikrobiologie MeSH
- financování organizované MeSH
- fungální léková rezistence MeSH
- lidé MeSH
- mykózy farmakoterapie mikrobiologie MeSH
- Pichia fyziologie izolace a purifikace patogenita účinky léků MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Pichia fabianii, a yeast rarely causing human infections, was isolated from the blood of a patient with aortic valve endocarditis. The isolates were initially identified biochemically as Candida pelliculosa, but based on direct sequencing of the ITS2 region of rRNA, they were subsequently reidentified as P. fabianii. Antifungal therapy with fluconazole and later with voriconazole led to the development of resistant variants which had high MIC values to both antifungals. Strong biofilm formation by this yeast could also have played a role in the development of its resistance and allowed for its persistence on the infected valve during antifungal therapy. To our knowledge, this is the first published case of endocarditis and the fourth human infection caused by this yeast species.
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- $a Department of Microbiology, University Hospital and Faculty of Medicine, Palacky University Olomouc, Czech Republic. petr.hamal@fnol.cz
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- $a Pichia fabianii, a yeast rarely causing human infections, was isolated from the blood of a patient with aortic valve endocarditis. The isolates were initially identified biochemically as Candida pelliculosa, but based on direct sequencing of the ITS2 region of rRNA, they were subsequently reidentified as P. fabianii. Antifungal therapy with fluconazole and later with voriconazole led to the development of resistant variants which had high MIC values to both antifungals. Strong biofilm formation by this yeast could also have played a role in the development of its resistance and allowed for its persistence on the infected valve during antifungal therapy. To our knowledge, this is the first published case of endocarditis and the fourth human infection caused by this yeast species.
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