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Effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice
F. Elzeinová, V. Nováková, D. Buckiová, A. Kubátová, J. Pěknicová
Language English Country United States
Document type Research Support, Non-U.S. Gov't
- MeSH
- Androgen Antagonists toxicity MeSH
- Genitalia, Male embryology drug effects MeSH
- Mice, Inbred ICR MeSH
- Mice MeSH
- Oxazoles toxicity MeSH
- Fetus drug effects MeSH
- Reverse Transcriptase Polymerase Chain Reaction MeSH
- Fungicides, Industrial toxicity MeSH
- Spermatogenesis MeSH
- Pregnancy MeSH
- Body Weight drug effects MeSH
- Testis metabolism drug effects MeSH
- Ubiquitin metabolism MeSH
- Organ Size drug effects MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups.
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- $a Laboratory of Diagnostics for Reproductive Medicine, Institute of Biotechnology, Academy of Sciences of the Czech Republic, v. v. i., Prague, Czech Republic.
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- $a The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups.
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