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Comparison of different doses of antigen for intradermal administration in pigs: the Actinobacillus pleuropneumoniae model
J Bernardy, K Nechvatalova, J Krejci, H Kudlackova, I Brazdova, Z Kucerova, M Faldyna
Jazyk angličtina Země Nizozemsko
Typ dokumentu srovnávací studie, práce podpořená grantem
NLK
ProQuest Central
od 2002-01-01 do Před 2 měsíci
Nursing & Allied Health Database (ProQuest)
od 2002-01-01 do Před 2 měsíci
Health & Medicine (ProQuest)
od 2002-01-01 do Před 2 měsíci
Family Health Database (ProQuest)
od 2002-01-01 do Před 2 měsíci
Health Management Database (ProQuest)
od 2002-01-01 do Před 2 měsíci
Public Health Database (ProQuest)
od 2002-01-01 do Před 2 měsíci
ScienceDirect (archiv)
od 1993-01-01 do 2009-12-31
- MeSH
- Actinobacillus pleuropneumoniae imunologie patogenita MeSH
- bakteriální vakcíny aplikace a dávkování imunologie MeSH
- imunologická odpověď na dávku MeSH
- infekce bakteriemi rodu Actinobacillus imunologie mikrobiologie patologie prevence a kontrola MeSH
- injekce intradermální MeSH
- nemoci prasat imunologie mikrobiologie patologie prevence a kontrola MeSH
- plíce mikrobiologie patologie MeSH
- prasata MeSH
- protilátky bakteriální krev MeSH
- výsledek terapie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
- srovnávací studie MeSH
The intensity of antibody responses and level of protection against challenge infection induced by Actinobacillus pleuropneumoniae (APP) were compared in piglets vaccinated intramuscularly with different vaccination doses of a subunit vaccine. Secondary antibody responses to APP exotoxins induced by the intradermally administered diluted vaccines did not differ from those induced by undiluted vaccines administered either intradermally or intramuscularly. The level of protection measured by the clinical course of challenge infection to the extent of lung lesions was significantly higher in animals vaccinated with a three-time diluted vaccine in comparison with animals that were administered intramuscularly or intradermally with the most concentrated or the most diluted vaccines.
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- $a The intensity of antibody responses and level of protection against challenge infection induced by Actinobacillus pleuropneumoniae (APP) were compared in piglets vaccinated intramuscularly with different vaccination doses of a subunit vaccine. Secondary antibody responses to APP exotoxins induced by the intradermally administered diluted vaccines did not differ from those induced by undiluted vaccines administered either intradermally or intramuscularly. The level of protection measured by the clinical course of challenge infection to the extent of lung lesions was significantly higher in animals vaccinated with a three-time diluted vaccine in comparison with animals that were administered intramuscularly or intradermally with the most concentrated or the most diluted vaccines.
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