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Comparison of different doses of antigen for intradermal administration in pigs: the Actinobacillus pleuropneumoniae model
J Bernardy, K Nechvatalova, J Krejci, H Kudlackova, I Brazdova, Z Kucerova, M Faldyna
Language English Country Netherlands
Document type Comparative Study, Research Support, Non-U.S. Gov't
NLK
ProQuest Central
from 2002-01-01 to 2 months ago
Nursing & Allied Health Database (ProQuest)
from 2002-01-01 to 2 months ago
Health & Medicine (ProQuest)
from 2002-01-01 to 2 months ago
Family Health Database (ProQuest)
from 2002-01-01 to 2 months ago
Health Management Database (ProQuest)
from 2002-01-01 to 2 months ago
Public Health Database (ProQuest)
from 2002-01-01 to 2 months ago
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Actinobacillus pleuropneumoniae immunology pathogenicity MeSH
- Bacterial Vaccines administration & dosage immunology MeSH
- Dose-Response Relationship, Immunologic MeSH
- Actinobacillus Infections immunology microbiology pathology prevention & control MeSH
- Injections, Intradermal MeSH
- Swine Diseases immunology microbiology pathology prevention & control MeSH
- Lung microbiology pathology MeSH
- Swine MeSH
- Antibodies, Bacterial blood MeSH
- Treatment Outcome MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
The intensity of antibody responses and level of protection against challenge infection induced by Actinobacillus pleuropneumoniae (APP) were compared in piglets vaccinated intramuscularly with different vaccination doses of a subunit vaccine. Secondary antibody responses to APP exotoxins induced by the intradermally administered diluted vaccines did not differ from those induced by undiluted vaccines administered either intradermally or intramuscularly. The level of protection measured by the clinical course of challenge infection to the extent of lung lesions was significantly higher in animals vaccinated with a three-time diluted vaccine in comparison with animals that were administered intramuscularly or intradermally with the most concentrated or the most diluted vaccines.
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