BACKGROUND: High-sensitivity C-reactive protein is an important biomarker of systemic inflammation. We studied the contribution to cardiovascular risk of increased high-sensitivity C-reactive protein in patients with type 2 diabetes with or without concomitant metabolic syndrome. MATERIAL/METHODS: The series included 381 patients (199 men, 182 women; median age, 66 years; age range, 50-80 years) with a mean duration of type 2 diabetes of 9+/-8 years. Standard physical examinations and laboratory investigations were administered to all patients. Modified National Cholesterol Education Program III criteria for defining the metabolic syndrome were used. High-sensitivity C-reactive protein was estimated by immunoturbidimetry and other laboratory tests using standard methods. RESULTS: High-sensitivity C-reactive protein correlated (Spearman's correlation) significantly positively with body mass index and waist size, fasting plasma triglyceride levels, apolipoprotein-B, gamma glutamyl transferase, homeostasis model assessment of insulin resistance, and fibrinogen, and negatively with high-density lipoprotein cholesterol. However, only waist, fibrinogen, apolipoprotein-B, plasma glucose, and gamma glutamyl transferase levels appeared to be associated with high-sensitivity C-reactive protein on multiple logistic regression model analyses. In those diabetic patients with concomitant metabolic syndrome, the hypertriglyceridemic waist appeared to be a major factor for an increased high-sensitivity C-reactive protein concentration. CONCLUSIONS: The hypertriglyceridemic waist contributes to the metabolic syndrome and most likely is an important factor increasing high-sensitivity C-reactive protein levels and consequently, relative coronary risk in patients with type 2 diabetes of any sex and age. PMID:18667998[PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, SubstancesPublication TypesResearch Support, Non-U.S. Gov'tMeSH TermsAge DistributionAgedAged, 80 and overC-Reactive Protein/analysis*Diabetes Mellitus, Type 2/blood*Diabetes Mellitus, Type 2/complications*Diabetes Mellitus, Type 2/physiopathologyFemaleHumansHypertriglyceridemia/bloodHypertriglyceridemia/complicationsHypertriglyceridemia/physiopathology*MaleMetabolic Syndrome X/blood*Metabolic Syndrome X/complications*Metabolic Syndrome X/physiopathologyMiddle AgedStatistics, NonparametricWaist-Hip Ratio*SubstancesC-Reactive Protein LinkOut - more resourcesFull Text SourcesMedical Science International, Ltd. - PDFMedicalTriglycerides - MedlinePlus Health InformationMetabolic Syndrome - MedlinePlus Health InformationDiabetes - MedlinePlus Health Information • Supplemental Content Related citations [The prevalence of metabolic syndrome in middle-aged in Kaunas population]. [Medicina (Kaunas). 2005] [The prevalence of metabolic syndrome in middle-aged in Kaunas population]. Gustiene O, Slapikas R, Klumbiene J, Sakalauskiene G, Kubilius R, Bagdzeviciute S, Zaliunas R. Medicina (Kaunas). 2005; 41(10):867-76. The hypertriglyceridemic waist phenotype versus the National Cholesterol Education Program-Adult Treatment Panel III and International Diabetes Federation clinical criteria to identify high-risk men with an altered cardiometabolic risk profile. [Metabolism. 2009] The hypertriglyceridemic waist phenotype versus the National Cholesterol Education Program-Adult Treatment Panel III and International Diabetes Federation clinical criteria to identify high-risk men with an altered cardiometabolic risk profile. Blackburn P, Lemieux I, Alméras N, Bergeron J, Côté M, Tremblay A, Lamarche B, Després JP. Metabolism. 2009 Aug; 58(8):1123-30. Epub 2009 Jun 18.Meal testing and postprandial state of type 2 diabetic patients with metabolic syndrome. [Rom J Intern Med. 2005] Meal testing and postprandial state of type 2 diabetic patients with metabolic syndrome. Brădescu OM, Georgescu M, Ifrim S, Ioacără S, Ionescu-Tîrgovişte C. Rom J Intern Med. 2005; 43(1-2):97-113. Review Hypertriglyceridemic waist: a useful screening phenotype in preventive cardiology? [Can J Cardiol. 2007] Review Hypertriglyceridemic waist: a useful screening phenotype in preventive cardiology? Lemieux I, Poirier P, Bergeron J, Alméras N, Lamarche B, Cantin B, Dagenais GR, Després JP. Can J Cardiol. 2007 Oct; 23 Suppl B:23B-31B. Review Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? [Circulation. 2004] Review Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? Ridker PM, Wilson PW, Grundy SM. Circulation. 2004 Jun 15; 109(23):2818-25. See reviews... See all... Cited by 1 PubMed Central article Effect of a fat spread enriched with medium-chain triacylglycerols and a special fatty acid-micronutrient combination on cardiometabolic risk factors in overweight patients with diabetes. [Nutr Metab (Lond). 2011] Effect of a fat spread enriched with medium-chain triacylglycerols and a special fatty acid-micronutrient combination on cardiometabolic risk factors in overweight patients with diabetes. Siener R, Ehrhardt C, Bitterlich N, Metzner C. Nutr Metab (Lond). 2011 Apr 8; 8:21. Epub 2011 Apr 8.All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.Gene Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.Gene (GeneRIF) Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.HomoloGene HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry

Center of Preventive Cardiology 2nd Medical Department Charles University Prague Medical Faculty in Pilsen Pilsen Czech Republic