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Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7
M Vrabel, R Pohl, I Votruba, M Sajadi, SA Kovalenko, NP Ernsting, M Hocek
Jazyk angličtina Země Velká Británie
PubMed
18688477
DOI
10.1039/b805632c
Knihovny.cz E-zdroje
- MeSH
- 2,2'-dipyridyl chemie MeSH
- antivirové látky farmakologie MeSH
- financování organizované MeSH
- fotochemie MeSH
- Hepacivirus účinky léků MeSH
- kultivované buňky MeSH
- lidé MeSH
- ligandy MeSH
- mikrobiální testy citlivosti MeSH
- molekulární struktura MeSH
- nádorové buněčné linie MeSH
- organokovové sloučeniny chemie MeSH
- oxidace-redukce MeSH
- proliferace buněk účinky léků MeSH
- protinádorové látky farmakologie MeSH
- ruthenium chemie MeSH
- screeningové testy protinádorových léčiv MeSH
- tubercidin analogy a deriváty farmakologie chemická syntéza chemie MeSH
- Check Tag
- lidé MeSH
The synthesis of the title 7-deazaadenine 2'-deoxyribonucleosides bearing bipyridine, phenanthroline or terpyridine ligands linked to position 7 via an acetylene or phenylene spacer is reported based on aqueous cross-coupling reactions of unprotected 7-iodo-7-deaza-2'-deoxyadenosine with ligand-functionalized acetylenes or boronic acids. The aqueous cross-coupling with acetylene or boronate building blocks containing the Ru(bpy)(3)-type of complex gave the corresponding Ru-containing nucleosides. Photophysical and electrochemical properties were studied and the most efficient type of complex was selected for future luminescent and redox labelling of DNA. The title nucleosides also showed some cytostatic and anti-HCV activities.
Citace poskytuje Crossref.org
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