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Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis?

J. Petrášek, J.A. Hubáček, F. Stickel, J. Šperl, T. Berg, E. Ruf, H.E. Wichmann, A. Pfeufer, T. Meitinger, P. Trunečka, J. Špičák, M. Jirsa

. 2009 ; 47 (4) : 398-404.

Language English Country Germany

Persistent link   https://www.medvik.cz/link/bmc11009494

BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), produced by endotoxin-activated Kupffer cells, play a key role in the pathogenesis of alcoholic liver cirrhosis (ALC). Alleles TNFA -238A, IL1B -31T and variant IL1RN*2 of repeat polymorphism in the gene encoding the IL-1 receptor antagonist increase production of TNF-alpha and IL-1beta, respectively. Alleles CD14 -159T, TLR4 c.896G and TLR4 c.1196T modify activation of Kupffer cells by endotoxin. We confirmed the published associations between these common variants and genetic predisposition to ALC by means of a large case-control association study conducted on two Central European populations.

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$a BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), produced by endotoxin-activated Kupffer cells, play a key role in the pathogenesis of alcoholic liver cirrhosis (ALC). Alleles TNFA -238A, IL1B -31T and variant IL1RN*2 of repeat polymorphism in the gene encoding the IL-1 receptor antagonist increase production of TNF-alpha and IL-1beta, respectively. Alleles CD14 -159T, TLR4 c.896G and TLR4 c.1196T modify activation of Kupffer cells by endotoxin. We confirmed the published associations between these common variants and genetic predisposition to ALC by means of a large case-control association study conducted on two Central European populations.
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$a studie případů a kontrol $7 D016022
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$a Hubáček, Jaroslav, $d 1966- $7 nlk20050169367
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$a Ruf, Esther
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$a Wichmann, H.-Erich
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$a Pfeufer, Arne
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$a Trunečka, Pavel, $d 1957- $7 jn20000402405
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