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Cyclocondensation reaction of heterocyclic carbonyl compounds. Part XIII: synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines
T. Gucký, I. Fryšová, J. Slouka, M. Hajdúch, P. Džubák
European journal of medicinal chemistry.
2009 ;
44 (2) :
891-900.
Jazyk angličtina Země Francie
Perzistentní odkaz
https://www.medvik.cz/link/bmc11009708
- MeSH
- financování organizované MeSH
- lidé MeSH
- nádorové buněčné linie MeSH
- protinádorové látky chemie MeSH
- pyrazoly MeSH
- screeningové testy protinádorových léčiv MeSH
- triaziny farmakologie chemická syntéza MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
A series of the 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines have been synthesized in five steps. The cytotoxic activity of all of the newly synthesized compounds has been tested in vitro against five cancer cell lines. Several compounds demonstrated significant broad cytotoxic activity in low micromolar range, while others were selectively active against lung adenocarcinoma cell line A549.
Citace poskytuje Crossref.org
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