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Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons
E. Šťastná, H. Chodounská, V. Pouzar, V. Kapras, J. Borovská, O. Cais, L. Vyklický, jr.
Language English Country United States
Persistent link
https://www.medvik.cz/link/bmc11009794
- MeSH
- Electric Conductivity MeSH
- Financing, Organized MeSH
- Hippocampus cytology MeSH
- Inhibitory Concentration 50 MeSH
- Rats MeSH
- Cells, Cultured MeSH
- Patch-Clamp Techniques MeSH
- Neurons metabolism drug effects MeSH
- Pregnanes pharmacology chemical synthesis chemistry MeSH
- Receptors, N-Methyl-D-Aspartate antagonists & inhibitors MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
The synthesis of several novel 5alpha- and 5beta-20-oxo-pregnane derivatives substituted in the position 3 and 7 of the steroid skeleton is described. Activity of synthesized compounds was studied in voltage-clamped cultured rat hippocampal neurons. Substituted derivatives inhibited NMDA-elicited neuronal activity. The relationship between biological activity and structure is discussed.
References provided by Crossref.org
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- $a Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i.,166 10 Prague 6, Czech Republic.
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- $a The synthesis of several novel 5alpha- and 5beta-20-oxo-pregnane derivatives substituted in the position 3 and 7 of the steroid skeleton is described. Activity of synthesized compounds was studied in voltage-clamped cultured rat hippocampal neurons. Substituted derivatives inhibited NMDA-elicited neuronal activity. The relationship between biological activity and structure is discussed.
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