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Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons
E. Šťastná, H. Chodounská, V. Pouzar, V. Kapras, J. Borovská, O. Cais, L. Vyklický, jr.
Jazyk angličtina Země Spojené státy americké
Perzistentní odkaz
https://www.medvik.cz/link/bmc11009794
- MeSH
- elektrická vodivost MeSH
- financování organizované MeSH
- hipokampus cytologie MeSH
- inhibiční koncentrace 50 MeSH
- krysa rodu rattus MeSH
- kultivované buňky MeSH
- metoda terčíkového zámku MeSH
- neurony metabolismus účinky léků MeSH
- pregnany farmakologie chemická syntéza chemie MeSH
- receptory N-methyl-D-aspartátu antagonisté a inhibitory MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
The synthesis of several novel 5alpha- and 5beta-20-oxo-pregnane derivatives substituted in the position 3 and 7 of the steroid skeleton is described. Activity of synthesized compounds was studied in voltage-clamped cultured rat hippocampal neurons. Substituted derivatives inhibited NMDA-elicited neuronal activity. The relationship between biological activity and structure is discussed.
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- bmc11009794
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- 20130422195050.0
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- 110511s2009 xxu e eng||
- 009
- AR
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- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
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- $a eng
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- $a xxu
- 100 1_
- $a Šťastná, Eva $7 xx0068402
- 245 10
- $a Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons / $c E. Šťastná, H. Chodounská, V. Pouzar, V. Kapras, J. Borovská, O. Cais, L. Vyklický, jr.
- 314 __
- $a Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i.,166 10 Prague 6, Czech Republic.
- 520 9_
- $a The synthesis of several novel 5alpha- and 5beta-20-oxo-pregnane derivatives substituted in the position 3 and 7 of the steroid skeleton is described. Activity of synthesized compounds was studied in voltage-clamped cultured rat hippocampal neurons. Substituted derivatives inhibited NMDA-elicited neuronal activity. The relationship between biological activity and structure is discussed.
- 590 __
- $a bohemika - dle Pubmed
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- $a zvířata $7 D000818
- 650 _2
- $a kultivované buňky $7 D002478
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- $a elektrická vodivost $7 D004553
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- $a inhibiční koncentrace 50 $7 D020128
- 650 _2
- $a neurony $x metabolismus $x účinky léků $7 D009474
- 650 _2
- $a metoda terčíkového zámku $7 D018408
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- $a pregnany $x farmakologie $x chemická syntéza $x chemie $7 D011278
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- $a krysa rodu Rattus $7 D051381
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- $a receptory N-methyl-D-aspartátu $x antagonisté a inhibitory $7 D016194
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- $a financování organizované $7 D005381
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- $a Chodounská, Hana $7 xx0168202
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- $a Pouzar, Vladimír, $d 1951-2013 $7 jn20010310027
- 700 1_
- $a Kapras, Vojtěch. $7 _AN063974
- 700 1_
- $a Borovská, Jiřina. $7 _AN045557
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- $a Cais, Ondřej. $7 _AN045554
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- $t Steroids $w MED00004438 $g Roč. 74, č. 2 (2009), s. 256-263 $x 0039-128X
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- $a ok $b bmc $g 839170 $s 703188
- BAS __
- $a 3
- BMC __
- $a 2009 $b 74 $c 2 $d 256-263 $i 0039-128X $m Steroids $n Steroids $x MED00004438
- LZP __
- $a 2011-2B09/jvme
