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Functional polymorphism of interferon-? (IFN-?) gene +874T/A polymorphism is associated with pulmonary tuberculosis in Zahedan, Southeast Iran

Hashemi M., Sharifi-Mood B., Nezamdoost M., Moazeni-Roodi A., Naderi M., Kouhpayeh H., Taheri M., Ghavami S.

. 2011 ; 112 (1) : 38-43.

Jazyk angličtina Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc11015301

Concerning the key role of interferon-? (IFN-?) in the protective immunity against Mycobacterium tuberculosis, we aimed to find the possible association between single nucleotide polymorphism of IFN-? +874T/A (rs61923114) and pulmonary tuberculosis (PTB). This case-control study was performed on 142 PTB patients and 166 healthy subjects. Genotype analysis was done using amplification refractory mutation system-PCR (ARMS-PCR). We found that the AA genotype of +874A/T IFN-? is a risk factor for PTB (OR = 3.333, 95% CI = 1.537-7.236, p=0.002). The results showed that the +874A allele frequency was higher in PTB than in normal subjects (OR = 1.561, 95% CI = 1.134-2.480, p=0.007). In conclusion, significant association was found between the IFN-? +874T/A polymorphism (rs61923114) and susceptibility to PTB in a sample of Iranian population.

Bibliografie atd.

Lit.: 26

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$a Concerning the key role of interferon-? (IFN-?) in the protective immunity against Mycobacterium tuberculosis, we aimed to find the possible association between single nucleotide polymorphism of IFN-? +874T/A (rs61923114) and pulmonary tuberculosis (PTB). This case-control study was performed on 142 PTB patients and 166 healthy subjects. Genotype analysis was done using amplification refractory mutation system-PCR (ARMS-PCR). We found that the AA genotype of +874A/T IFN-? is a risk factor for PTB (OR = 3.333, 95% CI = 1.537-7.236, p=0.002). The results showed that the +874A allele frequency was higher in PTB than in normal subjects (OR = 1.561, 95% CI = 1.134-2.480, p=0.007). In conclusion, significant association was found between the IFN-? +874T/A polymorphism (rs61923114) and susceptibility to PTB in a sample of Iranian population.
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