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Elektrochemická analýza poškození, hybridizace a dalších interakcí DNA
[Electrochemical analysis of DNA damage, hybridization and interactions]

Jan Vacek, Luděk Havran, Miroslav Fojta

. 2011 ; 105 (1) : 15-26.

Language Czech Country Czech Republic

Persistent link   https://www.medvik.cz/link/bmc11016246

Modern trends in electrochemical sensing deoxyribonucleic acids (DNA), particularly the use of electrochemical sensors for detection of DNA damage or hybridization, are discussed. Applications of electrochemical methods such as AC voltammetry, square-wave voltammetry and constant current chronopotentiometry as well as use of mercury and carbon electrodes are presented. Special attention is paid to application of Hg amalgams and carbon (pyrolytic graphite, C paste or glassy C) electrodes for monitoring reduction and oxidation processes (label-free detection). Techniques and procedures used for DNA labeling with electroactive tags such as transition-metal (Os, Ru, Cu) complexes or redox mediators are described. DNA interactions with heavy metal ions, drugs, and proteins are also mentioned. The review does not intend to give a complete overview of the topics considered but, rather, to present some historic consequences and modern electrochemical methods used in DNA research.

Electrochemical analysis of DNA damage, hybridization and interactions

Bibliography, etc.

Lit.: 92

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$a Electrochemical analysis of DNA damage, hybridization and interactions
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$a Oddělení biofyzikální chemie a molekulární onkologie, Biofyzikální ústav, v.v.i. AV ČR, Královopolská 135, 612 65 Brno
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