• Je něco špatně v tomto záznamu ?

Protective effect of manganese in cadmium-induced hepatic oxidative damage, changes in cadmium distribution and trace elements level in mice

Vladislav Eybl, Dana Kotyzová

Jazyk angličtina Země Slovensko

Perzistentní odkaz   https://www.medvik.cz/link/bmc11025227

Oxidative tissue damage is considered an early sign of cadmium (Cd) toxicity and has been linked with carcinogenesis. Manganese(II) - at low doses, was found to act as a potent antioxidant against oxidative stress in different in vitro systems producing lipid peroxidation conditions. The present study investigates in vivo antioxidant effects of Mn2+ pretreatment in acute Cd intoxication with regard to lipid peroxidation, antioxidant defense system and cadmium distribution in the tissues of mice. Four groups of male mice (n=7–8) were used: Cd group was injected sc a single dose of CdCl2 • 21 H2O (7 mg/kg b.w.); Cd+Mn group was treated ip with MnCl2 • 4H2O (20 mg/kg b.w.) 24 hours before Cd intoxication; Mn group received manganese treatment only; Control group received saline only. Twenty-four hours after Cd intoxication an increased lipid peroxidation (p<0.05), depleted GSH level (p<0.01), increased activity of GSH-Px (p<0.05) and inhibited CAT activity (p<0.01) were found in Cd-treated group compared to controls. Manganese(II) pre-treatment either completely prevented (LP, GSH, GSH-Px) or significantly attenuated (CAT) these changes. Manganese(II) treatment alone decreased LP, enhanced hepatic GSH level and had no effect on antioxidant enzymes compared to control group. A significant increase of Cd concentration in the liver and decreased Cd concentration in the kidneys and testes were found in Cd+Mn treated mice compared to Cd-only treated group. The effect of manganese may result from a different metallothionein induction in particular organs. Manganese(II) pretreatment attenuated the interference of cadmium with Ca homeostasis, the alteration in Zn and Cu levels remained mostly unaffected.

Citace poskytuje Crossref.org

Bibliografie atd.

Lit.: 26

000      
00000naa 2200000 a 4500
001      
bmc11025227
003      
CZ-PrNML
005      
20140829092056.0
008      
110831s2010 xo e eng||
009      
AR
024    7_
$a 10.2478/v10102-010-0013-3 $2 doi
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xo
100    1_
$a Eybl, Vladislav, $d 1932-2019 $7 jk01030602
245    10
$a Protective effect of manganese in cadmium-induced hepatic oxidative damage, changes in cadmium distribution and trace elements level in mice / $c Vladislav Eybl, Dana Kotyzová
314    __
$a Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Medicine, Pilsen
504    __
$a Lit.: 26
520    9_
$a Oxidative tissue damage is considered an early sign of cadmium (Cd) toxicity and has been linked with carcinogenesis. Manganese(II) - at low doses, was found to act as a potent antioxidant against oxidative stress in different in vitro systems producing lipid peroxidation conditions. The present study investigates in vivo antioxidant effects of Mn2+ pretreatment in acute Cd intoxication with regard to lipid peroxidation, antioxidant defense system and cadmium distribution in the tissues of mice. Four groups of male mice (n=7–8) were used: Cd group was injected sc a single dose of CdCl2 • 21 H2O (7 mg/kg b.w.); Cd+Mn group was treated ip with MnCl2 • 4H2O (20 mg/kg b.w.) 24 hours before Cd intoxication; Mn group received manganese treatment only; Control group received saline only. Twenty-four hours after Cd intoxication an increased lipid peroxidation (p<0.05), depleted GSH level (p<0.01), increased activity of GSH-Px (p<0.05) and inhibited CAT activity (p<0.01) were found in Cd-treated group compared to controls. Manganese(II) pre-treatment either completely prevented (LP, GSH, GSH-Px) or significantly attenuated (CAT) these changes. Manganese(II) treatment alone decreased LP, enhanced hepatic GSH level and had no effect on antioxidant enzymes compared to control group. A significant increase of Cd concentration in the liver and decreased Cd concentration in the kidneys and testes were found in Cd+Mn treated mice compared to Cd-only treated group. The effect of manganese may result from a different metallothionein induction in particular organs. Manganese(II) pretreatment attenuated the interference of cadmium with Ca homeostasis, the alteration in Zn and Cu levels remained mostly unaffected.
650    _2
$a financování organizované $7 D005381
650    _2
$a zvířata $7 D000818
650    _2
$a myši $7 D051379
650    _2
$a oxidační stres $x účinky léků $7 D018384
650    _2
$a otrava kadmiem $x terapie $7 D002105
650    _2
$a nemoci jater $x patofyziologie $7 D008107
650    _2
$a hořčík $x terapeutické užití $7 D008274
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a stopové prvky $7 D014131
700    1_
$a Kotyzová, Dana, $d 1955- $7 xx0080467
773    0_
$w MED00174076 $t Interdisciplinary toxicology $g Roč. 3, č. 2 (2010), s. 68-72 $x 1337-6853
856    41
$u http://www.intertox.sav.sk/ITX_pdf/03_02_2010/10102-Volume3_Issue_2-07_paper.pdf $y plný text volně přístupný
910    __
$a ABA008 $b B 2642 $c 547 $y 1 $z 0
990    __
$a 20110812063304 $b ABA008
991    __
$a 20140829092442 $b ABA008
999    __
$a ok $b bmc $g 869906 $s 735190
BAS    __
$a 3
BMC    __
$a 2010 $b 3 $c 2 $d 68-72 $m Interdisciplinary toxicology $x MED00174076
LZP    __
$a 2011-34/ipaš

Najít záznam

Citační ukazatele

Nahrávání dat ...