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Aglomerovaný monohydrát α-laktosy a bezvodá β-laktosa v přímém lisování tablet
[Agglomerated α-lactose monohydrate and anhydrous β-lactose in direct compression of tablets]

J. Mužíková, M. Neprašová, H. Faschingbauer

. 2012 ; 106 (1) : 36-40.

Jazyk čeština Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc12013275

Tensile strength and disintegration time of tablets from aglomerated α-lactose monohydrate or anhydrous β- lactose as well as the energy profile of compression (at 11 kN) were evaluated in dependence on the lubricant (Mg stearate) concentration and an addition of microcrystalline cellulose (25 %). No statistically significant differences were found between the corresponding values of tensile strength for tablets from both lactoses. Microcrystalline cellulose increased the strength, shortened the disintegration times and markedly decreased the differences in compression energies and plasticity of both types of tablets. Mg stearate prolonged the disintegration times and markedly decreased the tablet strength only in the presence of microcrystalline cellulose. The disintegration times were markedly longer for the tablets from anhydrous β-lactose. The total energy of compression and plasticity were higher for aglomerated α-lactose monohydrate tablets.

Agglomerated α-lactose monohydrate and anhydrous β-lactose in direct compression of tablets

Obsahuje 1 tabulku

Bibliografie atd.

Literatura

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$a Tensile strength and disintegration time of tablets from aglomerated α-lactose monohydrate or anhydrous β- lactose as well as the energy profile of compression (at 11 kN) were evaluated in dependence on the lubricant (Mg stearate) concentration and an addition of microcrystalline cellulose (25 %). No statistically significant differences were found between the corresponding values of tensile strength for tablets from both lactoses. Microcrystalline cellulose increased the strength, shortened the disintegration times and markedly decreased the differences in compression energies and plasticity of both types of tablets. Mg stearate prolonged the disintegration times and markedly decreased the tablet strength only in the presence of microcrystalline cellulose. The disintegration times were markedly longer for the tablets from anhydrous β-lactose. The total energy of compression and plasticity were higher for aglomerated α-lactose monohydrate tablets.
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