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Pharmacokinetics of acetylcholinesterase reactivator K203 and consequent evaluation of low molecular weight antioxidants/markers of oxidative stress

Jana Žďárová Karasová, Daniela Hnídková, Miroslav Pohanka, Kamil Musílek, Robert Peter Chilcott, Kamil Kuča

. 2012 ; 10 (2) : 71-78.

Language English Country Czech Republic

Persistent link   https://www.medvik.cz/link/bmc12017061

Oxime K203 is a new compound designed to be used as an acetylcholinesterase reactivator for the treatment of intoxication following exposure to tabun and certain pesticides. After intramuscular administration of a therapeutic (23 mg/kg) dose, the time-course of plasma concentrations of K203 in rats was determined by HPLC. Maximum concentrations were reached between 40 and 60 min (16.5±2.1 μg/ml in 40 min and 16.6±2.0 in 60 min, respectively) with the concentration being relatively constant during this period. There was no significant effect on the plasma concentration of thiobarbituric acid reactive substances (TBARS) during the administration of K203, indicating an absence of oxidative stress. Indeed, administration of K203 led to a significant increase in low molecular weight antioxidants which could tentatively be interpreted as representing a beneficial effect.

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Literatura

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$a Žďárová Karasová, Jana, $d 1982- $7 xx0099787 $u Department of Public Health, Faculty of Health Sciences, Defence University, Hradec Králové; University Hospital, Hradec Králové
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$a Pharmacokinetics of acetylcholinesterase reactivator K203 and consequent evaluation of low molecular weight antioxidants/markers of oxidative stress / $c Jana Žďárová Karasová, Daniela Hnídková, Miroslav Pohanka, Kamil Musílek, Robert Peter Chilcott, Kamil Kuča
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$a Oxime K203 is a new compound designed to be used as an acetylcholinesterase reactivator for the treatment of intoxication following exposure to tabun and certain pesticides. After intramuscular administration of a therapeutic (23 mg/kg) dose, the time-course of plasma concentrations of K203 in rats was determined by HPLC. Maximum concentrations were reached between 40 and 60 min (16.5±2.1 μg/ml in 40 min and 16.6±2.0 in 60 min, respectively) with the concentration being relatively constant during this period. There was no significant effect on the plasma concentration of thiobarbituric acid reactive substances (TBARS) during the administration of K203, indicating an absence of oxidative stress. Indeed, administration of K203 led to a significant increase in low molecular weight antioxidants which could tentatively be interpreted as representing a beneficial effect.
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$a Hnídková, Daniela. $7 _AN067901 $u Department of Public Health, Faculty of Health Sciences, Defence University, Hradec Králové
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$a Pohanka, Miroslav $7 hka2010563580 $u University Hospital, Hradec Králové; Center of Advances Studies, Faculty of Health Sciences, Defence University, Hradec Králové
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$a Musílek, Kamil, $d 1980- $7 xx0135628 $u University Hospital, Hradec Králové; Department of Chemistry, Faculty of Science, University of Hradec Králové, Hradec Králové
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$a Kuča, Kamil, $d 1978- $7 xx0041831 $u University Hospital, Hradec Králové; Center of Advances Studies, Faculty of Health Sciences, Defence University, Hradec Králové
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