Oxime K203 is a new compound designed to be used as an acetylcholinesterase reactivator for the treatment of intoxication following exposure to tabun and certain pesticides. After intramuscular administration of a therapeutic (23 mg/kg) dose, the time-course of plasma concentrations of K203 in rats was determined by HPLC. Maximum concentrations were reached between 40 and 60 min (16.5±2.1 μg/ml in 40 min and 16.6±2.0 in 60 min, respectively) with the concentration being relatively constant during this period. There was no significant effect on the plasma concentration of thiobarbituric acid reactive substances (TBARS) during the administration of K203, indicating an absence of oxidative stress. Indeed, administration of K203 led to a significant increase in low molecular weight antioxidants which could tentatively be interpreted as representing a beneficial effect.
- MeSH
- antioxidancia farmakokinetika terapeutické užití MeSH
- experimenty na zvířatech MeSH
- financování organizované MeSH
- krevní plazma chemie MeSH
- organofosfáty antagonisté a inhibitory MeSH
- oxidační stres účinky léků MeSH
- oximy farmakokinetika terapeutické užití MeSH
- potkani Wistar MeSH
- reaktivátory cholinesterasy farmakokinetika terapeutické užití MeSH
- statistika jako téma MeSH
- vysokoúčinná kapalinová chromatografie metody využití MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
