-
Something wrong with this record ?
BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas
Katerina Vrzalikova, Ciaran Bernard John Woodman, Paul Gerard Murray
Language English Country Czech Republic
Document type Research Support, Non-U.S. Gov't, Review
NLK
Directory of Open Access Journals
from 2001
Free Medical Journals
from 1998
Medline Complete (EBSCOhost)
from 2007-06-01
ROAD: Directory of Open Access Scholarly Resources
from 2001
- MeSH
- Lymphoma, B-Cell genetics virology MeSH
- Cell Differentiation genetics MeSH
- Down-Regulation MeSH
- Immunoglobulins biosynthesis MeSH
- Humans MeSH
- Plasma Cells physiology MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Repressor Proteins physiology genetics MeSH
- Genes, Tumor Suppressor physiology MeSH
- Herpesvirus 4, Human physiology MeSH
- Germinal Center physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. Methods and results. This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas. Conclusions. BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.
References provided by Crossref.org
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12020680
- 003
- CZ-PrNML
- 005
- 20121112095322.0
- 007
- ta
- 008
- 120725s2012 xr d f 000 0eng||
- 009
- AR
- 024 7_
- $a 10.5507/bp.2012.003 $2 doi
- 040 __
- $a ABA008 $d ABA008 $e AACR2 $b cze
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Vrzalíková, Kateřina. $7 _AN059363 $u School of Cancer Sciences, University of Birmingham, Birmingham; Department of Clinical and Molecular Pathology and Institute of Molecular and Translation Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc
- 245 10
- $a BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas / $c Katerina Vrzalikova, Ciaran Bernard John Woodman, Paul Gerard Murray
- 504 __
- $a Literatura $b 76
- 520 9_
- $a The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. Methods and results. This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas. Conclusions. BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.
- 650 02
- $a zvířata $7 D000818
- 650 02
- $a buněčná diferenciace $x genetika $7 D002454
- 650 02
- $a down regulace $7 D015536
- 650 02
- $a regulace genové exprese u nádorů $7 D015972
- 650 02
- $a tumor supresorové geny $x fyziologie $7 D016147
- 650 02
- $a zárodečné centrum lymfatické uzliny $x fyziologie $7 D018858
- 650 02
- $a virus Epsteinův-Barrové $x fyziologie $7 D004854
- 650 02
- $a lidé $7 D006801
- 650 02
- $a imunoglobuliny $x biosyntéza $7 D007136
- 650 02
- $a B-buněčný lymfom $x genetika $x virologie $7 D016393
- 650 02
- $a plazmatické buňky $x fyziologie $7 D010950
- 650 02
- $a represorové proteiny $x fyziologie $x genetika $7 D012097
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Woodman, Ciaran Bernard John $u School of Cancer Sciences, University of Birmingham, Birmingham
- 700 1_
- $a Murray, Paul G. $7 xx0165205 $u School of Cancer Sciences, University of Birmingham, Birmingham; Department of Clinical and Molecular Pathology and Institute of Molecular and Translation Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc
- 773 0_
- $t Biomedical papers $x 1213-8118 $g Roč. 156, č. 1 (2012), s. 1-6 $w MED00012606
- 856 41
- $u http://biomed.papers.upol.cz/pdfs/bio/2012/01/01.pdf $y plný text volně přístupný
- 910 __
- $a ABA008 $b A 1502 $c 958 $y 2
- 990 __
- $a 20120725124231 $b ABA008
- 991 __
- $a 20121112095336 $b ABA008
- 999 __
- $a ok $b bmc $g 914861 $s 777956
- BAS __
- $a 3
- BMC __
- $a 2012 $b 156 $c 1 $d 1-6 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
- LZP __
- $a 2012-13/mkme
