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Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid

Michaela Kralikova, Jitka Melounova, Igor Crha, Milena Matejovicova, Jana Zakova, Jiri Jarkovsky, Jaroslava Tallova

. 2011 ; 28 (9) : 863-868. [pub] 20110705

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12022337

Grantová podpora
NS9661 MZ0 CEP - Centrální evidence projektů

Digitální knihovna NLK
Plný text - Článek
Zdroj

E-zdroje Online Plný text

NLK Free Medical Journals od 2008 do Před 1 rokem
PubMed Central od 1997 do Před 1 rokem
Europe PubMed Central od 1997 do Před 1 rokem
ProQuest Central od 1999-01-01 do Před 1 rokem
Medline Complete (EBSCOhost) od 2011-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 1999-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 1999-01-01 do 2017-12-31

Odkazy

PubMed 21728074
DOI 10.1007/s10815-011-9606-9
Knihovny.cz E-zdroje

PURPOSE: To determine intraindividual variability in concentrations of homocysteine and related thiols in follicular fluids of particular follicles after ovarian stimulation and assess the differences between follicles with/or without oocytes. METHODS: HPLC-FD analysis of plasma and follicular fluid cysteine, homocysteine, cysteinylglycine and glutathione in women undergoing IVF. RESULTS: In blood plasma, the homocysteine, cysteine, and cysteinylglycine concentrations decreased significantly during stimulation with rec FSH (p<0.001). We found significant differences in concentrations of cysteine and glutathione between follicles with or without retrieved oocytes. High intraindividual variability in concentrations of thiols was determined. CONCLUSIONS: The concentration variability of thiols between single follicles is very high and we recommend mean at least from 3 follicles with/or without oocytes for characterization of each woman. It is the best to examine individual follicles for further research and analysis of fertility outcomes.

Citace poskytuje Crossref.org

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