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Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells
M. Slámová, A. Skallová, J. Páleníková, J. Kopecký,
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1997 to 1 year ago
Medline Complete (EBSCOhost)
from 1998-01-01 to 1 year ago
Wiley Online Library (archiv)
from 1997-01-01 to 2012-12-31
Wiley Free Content
from 1997 to 1 year ago
- MeSH
- Lymphocyte Activation MeSH
- Borrelia burgdorferi Group immunology MeSH
- CD4-Positive T-Lymphocytes immunology MeSH
- Cytokines secretion MeSH
- Dendritic Cells immunology MeSH
- Phagocytosis MeSH
- Immunologic Factors immunology MeSH
- Ixodes microbiology MeSH
- Mice, Inbred C3H MeSH
- Mice MeSH
- Saliva immunology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Interaction between mouse dendritic cells (DCs) and Borrelia afzelii spirochetes was monitored on three different levels: phagocytosis of spirochetes by DCs, production of cytokines by Borrelia-stimulated DCs and the ability of Borrelia-exposed DCs to activate specific CD4+ T lymphocytes. The effect of Ixodes ricinus tick saliva on each of these interactions was examined. Tick saliva was shown to decrease the number of phagocytosing DCs. The ability of Borrelia-exposed DCs to induce both proliferation and IL-2 production by specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have shown an inhibitory effect of tick saliva on the production of both Th1 (TNF-α and IL-6) and Th2 (IL-10) cytokines by DCs. Our data reveal a complex inhibitory effect of tick saliva on Borrelia-DCs interaction.
References provided by Crossref.org
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