Reactivation effects of K203 and currently available oximes (obidoxime, HI-6) in combination with atropine on acetylcholinesterase activities in the brain parts of rats poisoned with tabun were studied. The activity was determined by quantitative histochemical and biochemical methods correlating between them very well. The tabun-induced changes in acetylcholinsterase activity as well as in reactivation potency of reactivators used were different in various parts of the brain. Pontomedullar area seems to be important for observed changes following tabun intoxication and its treatment. From the oximes studied, the reactivation effect of K203 was comparable with obidoxime; HI-6 was ineffective. Combination of bio- and histochemical methods allow fine differentiation among the action of different oximes following tabun poisoning.

Department of Toxicology Faculty of Military Health Sciences University of Defence Hradec Kralove Czech Republic

000      

00000naa a2200000 a 4500

001      

bmc12024383

003      

CZ-PrNML

005      

20121210100733.0

007      

ta

008      

120815s2012 enk f 000 0#eng||

009      

AR

024    7_

$a 10.3109/15376516.2011.596231 $2 doi

035    __

$a (PubMed)21851296

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a enk

100    1_

$a Bajgar, Jiri $u Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic. bajgar@pmfhk.cz

245    10

$a Combined approach to demonstrate acetylcholinesterase activity changes in the rat brain following tabun intoxication and its treatment / $c J. Bajgar, P. Hajek, J. Kassa, D. Slizova, O. Krs, JZ. Karasova, J. Fusek, L. Capek, VA. Voicu,

520    9_

$a Reactivation effects of K203 and currently available oximes (obidoxime, HI-6) in combination with atropine on acetylcholinesterase activities in the brain parts of rats poisoned with tabun were studied. The activity was determined by quantitative histochemical and biochemical methods correlating between them very well. The tabun-induced changes in acetylcholinsterase activity as well as in reactivation potency of reactivators used were different in various parts of the brain. Pontomedullar area seems to be important for observed changes following tabun intoxication and its treatment. From the oximes studied, the reactivation effect of K203 was comparable with obidoxime; HI-6 was ineffective. Combination of bio- and histochemical methods allow fine differentiation among the action of different oximes following tabun poisoning.

650    _2

$a zvířata $7 D000818

650    _2

$a mozek $x účinky léků $x enzymologie $x patologie $7 D001921

650    _2

$a mapování mozku $7 D001931

650    _2

$a chemické bojové látky $x otrava $7 D002619

650    _2

$a reaktivátory cholinesterázy $x aplikace a dávkování $x chemie $x farmakologie $x terapeutické užití $7 D002801

650    _2

$a cholinesterasy $x metabolismus $7 D002802

650    _2

$a ženské pohlaví $7 D005260

650    _2

$a molekulární struktura $7 D015394

650    _2

$a neurotoxické syndromy $x enzymologie $x patologie $x prevence a kontrola $7 D020258

650    _2

$a oximy $x aplikace a dávkování $x chemie $x farmakologie $x terapeutické užití $7 D010091

650    _2

$a organofosfáty $x otrava $7 D010755

650    _2

$a pyridinové sloučeniny $x aplikace a dávkování $x chemie $x farmakologie $x terapeutické užití $7 D011726

650    _2

$a krysa rodu Rattus $7 D051381

650    _2

$a potkani Wistar $7 D017208

655    _2

$a časopisecké články $7 D016428

655    _2

$a práce podpořená grantem $7 D013485

700    1_

$a Hajek, Petr

700    1_

$a Kassa, Jiri

700    1_

$a Slizova, Dasa

700    1_

$a Krs, Otakar

700    1_

$a Karasova, Jana Zdarova

700    1_

$a Fusek, Josef

700    1_

$a Capek, Lukas

700    1_

$a Voicu, Victor A

773    0_

$w MED00007380 $t Toxicology mechanisms and methods $x 1537-6524 $g Roč. 22, č. 1 (2012), s. 60-6

856    41

$u https://pubmed.ncbi.nlm.nih.gov/21851296 $y Pubmed

910    __

$a ABA008 $b sig $c sign $y m

990    __

$a 20120815 $b ABA008

991    __

$a 20121210100810 $b ABA008

999    __

$a ok $b bmc $g 946531 $s 781711

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2012 $b 22 $c 1 $d 60-6 $i 1537-6524 $m Toxicology mechanisms and methods $n Toxicol Mech Methods $x MED00007380

LZP    __

$a Pubmed-20120815/12/02