-
Something wrong with this record ?
Cytogenetic manifestation of chromosome 11 duplication/amplification in acute myeloid leukemia
I. Šárová, J. Březinová, Z. Zemanová, S. Izáková, L. Lizcová, E. Malinová, A. Berková, J. Čermák, J. Maaloufová, L. Nováková, K. Michalová
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NR9481
MZ0
CEP Register
NR9227
MZ0
CEP Register
- MeSH
- Leukemia, Myeloid, Acute diagnosis genetics MeSH
- Gene Amplification MeSH
- Adult MeSH
- Gene Duplication MeSH
- In Situ Hybridization, Fluorescence MeSH
- Karyotyping MeSH
- Middle Aged MeSH
- Humans MeSH
- Chromosomes, Human, Pair 11 genetics MeSH
- Prognosis MeSH
- Aged MeSH
- Trisomy MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Gene amplification is a frequent genetic abnormality in solid tumors, and many oncogenes are activated in this way. In acute myeloid leukemia (AML), a frequent target of gene amplification is chromosome 11, particularly chromosome region 11q23, including the MLL (myeloid/lymphoid leukemia) gene. However, the number of other amplicons from the long arm of chromosome 11 has also been described. Duplication/amplification of chromosome 11 was found by cytogenetic methods in 10 of 119 newly diagnosed patients with AML. The amplification was presented as: amplification including only the 5' segment of the MLL gene (1 patient), trisomy 11 (3 patients), partial trisomy 11q (2 patients), isochromosome 11q (1 patient), and multiple amplification of specific regions (3 patients). In two cases, amplification involved parts of not only long arm but also of short arm of the chromosome 11: 11p15 and 11p11.1 to 11p13.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12025076
- 003
- CZ-PrNML
- 005
- 20241204104305.0
- 007
- ta
- 008
- 120816s2010 xxu f 000 0#eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.cancergencyto.2010.02.012 $2 doi
- 035 __
- $a (PubMed)20471515
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Šárová, Iveta $7 xx0212302 $u Cytogenetic Department, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic. iveta.sarova@uhkt.cz
- 245 10
- $a Cytogenetic manifestation of chromosome 11 duplication/amplification in acute myeloid leukemia / $c I. Šárová, J. Březinová, Z. Zemanová, S. Izáková, L. Lizcová, E. Malinová, A. Berková, J. Čermák, J. Maaloufová, L. Nováková, K. Michalová
- 520 9_
- $a Gene amplification is a frequent genetic abnormality in solid tumors, and many oncogenes are activated in this way. In acute myeloid leukemia (AML), a frequent target of gene amplification is chromosome 11, particularly chromosome region 11q23, including the MLL (myeloid/lymphoid leukemia) gene. However, the number of other amplicons from the long arm of chromosome 11 has also been described. Duplication/amplification of chromosome 11 was found by cytogenetic methods in 10 of 119 newly diagnosed patients with AML. The amplification was presented as: amplification including only the 5' segment of the MLL gene (1 patient), trisomy 11 (3 patients), partial trisomy 11q (2 patients), isochromosome 11q (1 patient), and multiple amplification of specific regions (3 patients). In two cases, amplification involved parts of not only long arm but also of short arm of the chromosome 11: 11p15 and 11p11.1 to 11p13.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a lidské chromozomy, pár 11 $x genetika $7 D002880
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a amplifikace genu $7 D005784
- 650 _2
- $a duplikace genu $7 D020440
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a hybridizace in situ fluorescenční $7 D017404
- 650 _2
- $a karyotypizace $7 D007621
- 650 _2
- $a akutní myeloidní leukemie $x diagnóza $x genetika $7 D015470
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a prognóza $7 D011379
- 650 _2
- $a trizomie $7 D014314
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Březinová, Jana, $d 1958- $7 xx0046958
- 700 1_
- $a Zemanová, Zuzana, $d 1962- $7 nlk20050170627
- 700 1_
- $a Izáková, Silvia $7 xx0118841
- 700 1_
- $a Lizcová, Libuše $7 xx0128719
- 700 1_
- $a Malinová, Eva $7 xx0158844
- 700 1_
- $a Berková, Adéla $7 xx0325890
- 700 1_
- $a Čermák, Jaroslav, $7 xx0053072 $d 1954-
- 700 1_
- $a Maaloufová, Jacqueline $7 xx0064317
- 700 1#
- $a Nováková, Ludmila. $7 _AN066932
- 700 1_
- $a Michalová, Kyra, $d 1942- $7 nlk19990073558
- 773 0_
- $w MED00001039 $t Cancer genetics and cytogenetics $x 1873-4456 $g Roč. 199, č. 2 (2010), s. 121-127
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/20471515 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y m $z 0
- 990 __
- $a 20120816 $b ABA008
- 991 __
- $a 20241204104300 $b ABA008
- 999 __
- $a ok $b bmc $g 947118 $s 782422
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2010 $b 199 $c 2 $d 121-127 $i 1873-4456 $m Cancer genetics and cytogenetics $n Cancer Genet Cytogenet $x MED00001039
- GRA __
- $a NR9481 $p MZ0
- GRA __
- $a NR9227 $p MZ0
- LZP __
- $a Pubmed-20120816/10/02
