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Cytotoxic activities of several geranyl-substituted flavanones
K. Šmejkal, J. Svačinová, T. Šlapetová, K. Schneiderová, S. Dall'Acqua, G. Innocenti, V. Závalová, P. Kollár, S. Chudík, R. Marek, O. Julínek, M. Urbanová, M. Kartal, M. Csöllei, K. Doležal
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20192247
DOI
10.1021/np900681y
Knihovny.cz E-resources
- MeSH
- Apoptosis drug effects MeSH
- Fibroblasts drug effects MeSH
- Flavanones chemistry isolation & purification pharmacology MeSH
- Antineoplastic Agents, Phytogenic chemistry isolation & purification pharmacology MeSH
- Plant Roots chemistry MeSH
- Plants, Medicinal chemistry MeSH
- Humans MeSH
- Magnoliopsida chemistry MeSH
- Molecular Structure MeSH
- Morus chemistry MeSH
- Nuclear Magnetic Resonance, Biomolecular MeSH
- Fruit chemistry MeSH
- Drug Screening Assays, Antitumor MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Turkey MeSH
Nine geranylated flavanones isolated from the fruits of Paulownia tomentosa (4-12) and two from the roots of Morus alba (13 and 14) were examined for cytotoxicity to selected human cancer cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using a calcein AM cytotoxicity assay. Cytotoxicity for the THP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards taxifolin (1), naringenin (2), and hesperetin (3) and with the standard anticancer drugs olomoucine II, diaziquone, and oxaliplatin and the antineoplastic compound camptothecin, and showed different levels of cytotoxicity. The effects of structural changes on cytotoxic activity, including geranyl substitution of the flavanone skeleton and the oxidation pattern of ring B of the flavanones, are discussed.
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