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No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer
T. Freiberger, B. Ravcuková, L. Grodecká, B. Kurecová, J. Jarkovský, D. Bartonková, V. Thon, J. Litzman
Language English Country Ireland
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NR9192
MZ0
CEP Register
- MeSH
- Fetal Blood MeSH
- Gene Frequency MeSH
- Genetic Association Studies MeSH
- Genotype MeSH
- Immunity, Maternally-Acquired genetics MeSH
- Immunoglobulin G biosynthesis blood genetics MeSH
- Humans MeSH
- Maternal-Fetal Exchange genetics immunology MeSH
- Histocompatibility Antigens Class I genetics immunology metabolism MeSH
- Minisatellite Repeats immunology MeSH
- DNA Mutational Analysis MeSH
- Infant, Newborn MeSH
- Polymorphism, Genetic MeSH
- Promoter Regions, Genetic MeSH
- Receptors, Fc genetics immunology metabolism MeSH
- Pregnancy MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The neonatal Fc receptor (FcRn) plays a critical role in maternal-fetal IgG transfer. Recently, a functionally active promoter polymorphism in the FCRN gene, represented by variable number of tandem repeats (VNTR), has been described. We analysed 103 single fetal samples and 103 paired maternal and fetal samples collected from umbilical cord blood of full-term neonates born from the 38th to the 41st week of pregnancy and detected no significant influence of maternal FCRN VNTR genotype on maternal IgG levels or of fetal FCRN VNTR genotype on fetal IgG levels or the fetal/maternal IgG ratio.
References provided by Crossref.org
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