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Nucleoside phosphonic acids in thymidine phosphorylase inhibition: structure-activity relationship
N. Panova, I. Kosiová, M. Petrová, V. Vanĕk, R. Liboska, S. Kovacková, P. Kocalka, S. Králíková, Z. Tocík, O. Páv, O. Paces, D. Rejman, I. Rosenberg,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18776555
DOI
10.1093/nass/nrn336
Knihovny.cz E-resources
- MeSH
- CHO Cells MeSH
- Cricetulus MeSH
- Enzyme Inhibitors chemistry pharmacology MeSH
- Cricetinae MeSH
- Phosphorous Acids chemistry MeSH
- Humans MeSH
- Nucleosides chemistry pharmacology MeSH
- Thymidine Phosphorylase antagonists & inhibitors chemistry MeSH
- Blood Platelets enzymology MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Cricetinae MeSH
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
A number of structurally diverse nucleoside phosphonic acids have been tested against human recombinant thymidine phosphorylase and human platelets supernatant using 2'-deoxy-5-nitrouridine as the substrate. We have selected several inhibitors working at micromolar level as lead structures for further evaluation.
References provided by Crossref.org
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