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Chiral phosphonate internucleotide linkage: a promising modification for chimeric oligonucleotides?
R. Liboska, M. Petrová, R. Pohl, M. Budesínsky, V. Hurychová, I. Rosenberg,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18776381
DOI
10.1093/nass/nrn160
Knihovny.cz E-resources
- MeSH
- DNA chemistry MeSH
- Endoribonucleases chemistry MeSH
- Isomerism MeSH
- Phosphorous Acids chemistry MeSH
- Oligodeoxyribonucleotides chemical synthesis chemistry MeSH
- RNA chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
We have synthesized two different groups of oligonucleotides containing chiral isopolar nonisosteric phosphonate internucleotide linkages, and studied their properties in combination with natural phosphodiester ones. The improved synthetic procedures for the monomers preparation are also reported.
References provided by Crossref.org
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