Chiral phosphonate internucleotide linkage: a promising modification for chimeric oligonucleotides?
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18776381
DOI
10.1093/nass/nrn160
PII: nrn160
Knihovny.cz E-resources
- MeSH
- DNA chemistry MeSH
- Endoribonucleases chemistry MeSH
- Isomerism MeSH
- Oligodeoxyribonucleotides chemical synthesis chemistry MeSH
- Organophosphonates chemistry MeSH
- RNA chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 2-5A-dependent ribonuclease MeSH Browser
- DNA MeSH
- Endoribonucleases MeSH
- Oligodeoxyribonucleotides MeSH
- Organophosphonates MeSH
- RNA MeSH
We have synthesized two different groups of oligonucleotides containing chiral isopolar nonisosteric phosphonate internucleotide linkages, and studied their properties in combination with natural phosphodiester ones. The improved synthetic procedures for the monomers preparation are also reported.
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