-
Je něco špatně v tomto záznamu ?
Analysis of Amaryllidaceae alkaloids from Chlidanthus fragrans by GC-MS and their cholinesterase activity
L. Cahlíková, K. Macáková, S. Zavadil, P. Jiros, L. Opletal, K. Urbanová, L. Jahodár
Natural product communications.
2011 ;
6 (5) :
603-606.
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc12026977
- MeSH
- alkaloidy amarylkovitých chemie izolace a purifikace MeSH
- cholinesterasové inhibitory chemie izolace a purifikace MeSH
- lidé MeSH
- liliovité chemie MeSH
- plynová chromatografie s hmotnostně spektrometrickou detekcí MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The underivatized alkaloid mixture extracted from the bulbs of Chlidanthus fragrans Herb. was investigated by capillary GC/MS for the first time. Fifteen known Amaryllidaceae alkaloids of five structure types were identified. The main alkaloids were tazzetine (9, tazettine-type), chlidanthine (2, galanthamine-type), belladine (8, belladine-type) and lycorine (12, lycorine-type). The alkaloid extract from the bulbs showed promising human blood acetylcholinesterase (IC50 = 20.1 +/- 2.9 microg/mL) and human plasma butyrylcholinesterase (IC50 = 136.8 +/- 6.9 microg/mL) inhibitory activity.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12026977
- 003
- CZ-PrNML
- 005
- 20230525090032.0
- 007
- ta
- 008
- 120816s2011 xxu f 000 0#eng||
- 009
- AR
- 035 __
- $a (PubMed)21615016
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Cahlíková, Lucie $u Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. cahlikova@fafcuni.cz
- 245 10
- $a Analysis of Amaryllidaceae alkaloids from Chlidanthus fragrans by GC-MS and their cholinesterase activity / $c L. Cahlíková, K. Macáková, S. Zavadil, P. Jiros, L. Opletal, K. Urbanová, L. Jahodár
- 520 9_
- $a The underivatized alkaloid mixture extracted from the bulbs of Chlidanthus fragrans Herb. was investigated by capillary GC/MS for the first time. Fifteen known Amaryllidaceae alkaloids of five structure types were identified. The main alkaloids were tazzetine (9, tazettine-type), chlidanthine (2, galanthamine-type), belladine (8, belladine-type) and lycorine (12, lycorine-type). The alkaloid extract from the bulbs showed promising human blood acetylcholinesterase (IC50 = 20.1 +/- 2.9 microg/mL) and human plasma butyrylcholinesterase (IC50 = 136.8 +/- 6.9 microg/mL) inhibitory activity.
- 650 _2
- $a alkaloidy amarylkovitých $x chemie $x izolace a purifikace $7 D047151
- 650 _2
- $a cholinesterasové inhibitory $x chemie $x izolace a purifikace $7 D002800
- 650 _2
- $a plynová chromatografie s hmotnostně spektrometrickou detekcí $7 D008401
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a liliovité $x chemie $7 D019668
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Macáková, Kateřina $7 xx0138072 $u Department of Pharmaceutical Botany and Ecology Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovskdho 1203, 500 05, Hradec Králové, Czech Republic
- 700 1_
- $a Zavadil, Stanislav
- 700 1_
- $a Jiroš, Pavel $7 xx0301845 $u Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10, Prague 6, Czech Republic
- 700 1_
- $a Opletal, Lubomír, $d 1952- $7 jn20000620258
- 700 1_
- $a Urbanová, Klára $u Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n. 2, CZ-166 10 Prague 6
- 700 1_
- $a Jahodář, Luděk, $d 1948- $7 jn20000620131 $u Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic
- 773 0_
- $w MED00180450 $t Natural product communications $x 1934-578X $g Roč. 6, č. 5 (2011), s. 603-606
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/21615016 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y m $z 0
- 990 __
- $a 20120816 $b ABA008
- 991 __
- $a 20230525090026 $b ABA008
- 999 __
- $a ok $b bmc $g 949019 $s 784323
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2011 $b 6 $c 5 $d 603-606 $i 1934-578X $m Natural product communications $n Nat Prod Commun $x MED00180450
- LZP __
- $b NLK122 $a Pubmed-20120816/11/02
