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Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides
P. Mader, J. Brynda, R. Gitto, S. Agnello, P. Pachl, CT. Supuran, A. Chimirri, P. Řezáčová
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
21395315
DOI
10.1021/jm2000213
Knihovny.cz E-zdroje
- MeSH
- inhibitory karboanhydras chemie metabolismus farmakologie MeSH
- isochinoliny chemie metabolismus farmakologie MeSH
- izoenzymy antagonisté a inhibitory chemie metabolismus MeSH
- karboanhydrasa II antagonisté a inhibitory chemie metabolismus MeSH
- konformace proteinů MeSH
- krystalografie rentgenová MeSH
- lidé MeSH
- molekulární modely MeSH
- substrátová specifita MeSH
- vazba proteinů MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Isoquinolinesulfonamides inhibit human carbonic anhydrases (hCAs) and display selectivity toward therapeutically relevant isozymes. The crystal structure of hCA II in complex with 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamide revealed unusual inhibitor binding. Structural analyses allowed for discerning the fine details of the inhibitor binding mode to the active site, thus providing clues for the future design of even more selective inhibitors for druggable isoforms such as the cancer associated hCA IX and neuronal hCA VII.
Dipartimento Farmaco Chimico Università di Messina Messina Italy
Laboratorio di Chimica Bioinorganica Università degli Studi di Firenze Italy
Citace poskytuje Crossref.org
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