Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Loci controlling lymphocyte production of interferon c after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility

M. Lipoldová, H. Havelková, J. Badalova, J. Vojtísková, L. Quan, M. Krulova, Y. Sohrabi, AP. Stassen, P. Demant

. 2010 ; 59 (2) : 203-213.

Language English Country Germany

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12027444

Low infiltration of lymphocytes into cancers is associated with poor prognosis, but the reasons why some patients exhibit a low and others a high infiltration of tumors are unknown. Previously we mapped four loci (Lynf1–Lynf4) controlling lymphocyte infiltration of mouse lung tumors. These loci do not encode any of the molecules that are involved in traffic of lymphocytes. Here we report a genetic relationship between these loci and the control of production of IFNγ in allogeneic mixed lymphocyte cultures (MLC). We found that IFNγ production by lymphocytes of O20/A mice is lower than by lymphocytes of OcB-9/Dem mice (both H2pz) stimulated in MLC by irradiated splenocytes of C57BL/10SnPh (H2b) or BALB/ cHeA (H2d) mice, or by ConA. IFNγ production in MLCs of individual (O20 9 OcB-9)F2mice stimulated by irradiated C57BL/10 splenocytes and genotyped for microsatellite markers revealed four IFNγ-controlling loci (Cypr4-Cypr7), each of which is closely linked with one of the four Lynf loci and with a cluster of susceptibility genes for different tumors. This suggests that inherited differences in certain lymphocyte responses may modify their propensity to infiltrate tumors and their capacity to affect tumor growth.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12027444
003      
CZ-PrNML
005      
20160224124507.0
007      
ta
008      
120816s2010 gw f 000 0#eng||
009      
AR
024    7_
$a 10.1007/s00262-009-0739-y $2 doi
035    __
$a (PubMed)19655140
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Lipoldová, Marie, $u Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Vídenká 1083, 14220 Prague 4, Czech Republic. lipoldova@img.cas.cz $d 1955- $7 xx0026260
245    10
$a Loci controlling lymphocyte production of interferon c after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility / $c M. Lipoldová, H. Havelková, J. Badalova, J. Vojtísková, L. Quan, M. Krulova, Y. Sohrabi, AP. Stassen, P. Demant
520    9_
$a Low infiltration of lymphocytes into cancers is associated with poor prognosis, but the reasons why some patients exhibit a low and others a high infiltration of tumors are unknown. Previously we mapped four loci (Lynf1–Lynf4) controlling lymphocyte infiltration of mouse lung tumors. These loci do not encode any of the molecules that are involved in traffic of lymphocytes. Here we report a genetic relationship between these loci and the control of production of IFNγ in allogeneic mixed lymphocyte cultures (MLC). We found that IFNγ production by lymphocytes of O20/A mice is lower than by lymphocytes of OcB-9/Dem mice (both H2pz) stimulated in MLC by irradiated splenocytes of C57BL/10SnPh (H2b) or BALB/ cHeA (H2d) mice, or by ConA. IFNγ production in MLCs of individual (O20 9 OcB-9)F2mice stimulated by irradiated C57BL/10 splenocytes and genotyped for microsatellite markers revealed four IFNγ-controlling loci (Cypr4-Cypr7), each of which is closely linked with one of the four Lynf loci and with a cluster of susceptibility genes for different tumors. This suggests that inherited differences in certain lymphocyte responses may modify their propensity to infiltrate tumors and their capacity to affect tumor growth.
650    _2
$a zvířata $7 D000818
650    _2
$a mapování chromozomů $7 D002874
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a genetické lokusy $7 D056426
650    _2
$a interferon gama $x biosyntéza $7 D007371
650    _2
$a isoantigeny $x imunologie $7 D007519
650    _2
$a test smíšené lymfocytární kultury $7 D007959
650    _2
$a tumor infiltrující lymfocyty $x imunologie $7 D016246
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a myši $7 D051379
650    _2
$a myši inbrední BALB C $7 D008807
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a mutantní kmeny myší $7 D008817
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Havelková, Helena $u Department of Molecular and Cellular Immunology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic $7 xx0065549
700    1_
$a Badalová, Jana $u Department of Molecular and Cellular Immunology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic $7 xx0193210
700    1_
$a Vojtísková, Jarmila $u Department of Molecular and Cellular Immunology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic
700    1_
$a Quan, Lei
700    1_
$a Krulová, Magdaléna $u Department of Molecular and Cellular Immunology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic $7 xx0083610
700    1_
$a Sohrabi, Yahya $u Department of Molecular and Cellular Immunology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic $7 _AN075250
700    1_
$a Stassen, Alphons P. $u Department of Genetics and Cell Biology, Maastricht University
700    1_
$a Démant, Peter, $d 1940- $u Department of Molecular and Cellular Biology, Roswell Park Cancer Institute $7 xx0063641
773    0_
$w MED00001041 $t Cancer immunology, immunotherapy CII $x 1432-0851 $g Roč. 59, č. 2 (2010), s. 203-213
856    41
$u https://pubmed.ncbi.nlm.nih.gov/19655140 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m $z 0
990    __
$a 20120816 $b ABA008
991    __
$a 20160224124224 $b ABA008
999    __
$a ok $b bmc $g 949486 $s 784790
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2010 $b 59 $c 2 $d 203-213 $i 1432-0851 $m Cancer immunology and immunotherapy $n Cancer Immunol Immunother $x MED00001041
LZP    __
$b NLK112 $a Pubmed-20120816/11/02

Find record

Citation metrics

Archiving options