• Je něco špatně v tomto záznamu ?

Synthesis and characterization of (Z)-5-arylmethylidene-rhodanines with photosynthesis-inhibiting properties

V. Opletalova, J. Dolezel, K. Kralova, M. Pesko, J. Kunes, J. Jampilek

. 2011 ; 16 (6) : 5207-27. [pub] 20110622

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12027487

A series of rhodanine derivatives was prepared. The synthetic approach, analytical and spectroscopic data of all synthesized compounds are presented. Lipophilicity of all the discussed rhodanine derivatives was analyzed using the RP-HPLC method. The compounds were tested for their ability to inhibit photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts and reduce chlorophyll content in freshwater alga Chlorella vulgaris. Structure-activity relationships between the chemical structure, physical properties and biological activities of the evaluated compounds are discussed. For majority of the tested compounds the lipophilicity of the compound and not electronic properties of the R1 substituent were decisive for PET-inhibiting activity. The most potent PET inhibitor was (5Z)-5-(4-bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (IC(50) = 3.0 μmol/L) and the highest antialgal activity was exhibited by (5Z)-5-(4-chlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (IC(50) = 1.3 μmol/L).

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12027487
003      
CZ-PrNML
005      
20130325063940.0
007      
ta
008      
120817e20110622sz f 000 0#eng||
009      
AR
024    7_
$a 10.3390/molecules16065207 $2 doi
035    __
$a (PubMed)21697777
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Opletalová, Veronika, $d 1955- $7 jn20000620259 $u Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. veronika.opletalova@faf.cuni.cz
245    10
$a Synthesis and characterization of (Z)-5-arylmethylidene-rhodanines with photosynthesis-inhibiting properties / $c V. Opletalova, J. Dolezel, K. Kralova, M. Pesko, J. Kunes, J. Jampilek
520    9_
$a A series of rhodanine derivatives was prepared. The synthetic approach, analytical and spectroscopic data of all synthesized compounds are presented. Lipophilicity of all the discussed rhodanine derivatives was analyzed using the RP-HPLC method. The compounds were tested for their ability to inhibit photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts and reduce chlorophyll content in freshwater alga Chlorella vulgaris. Structure-activity relationships between the chemical structure, physical properties and biological activities of the evaluated compounds are discussed. For majority of the tested compounds the lipophilicity of the compound and not electronic properties of the R1 substituent were decisive for PET-inhibiting activity. The most potent PET inhibitor was (5Z)-5-(4-bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (IC(50) = 3.0 μmol/L) and the highest antialgal activity was exhibited by (5Z)-5-(4-chlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (IC(50) = 1.3 μmol/L).
650    _2
$a Chlorella vulgaris $x účinky léků $x metabolismus $7 D048408
650    _2
$a chloroplasty $x účinky léků $x metabolismus $7 D002736
650    _2
$a transport elektronů $x účinky léků $7 D004579
650    _2
$a hydrofobní a hydrofilní interakce $7 D057927
650    _2
$a nukleární magnetická rezonance biomolekulární $7 D019906
650    _2
$a fotosyntéza $x účinky léků $7 D010788
650    _2
$a rhodanin $x analogy a deriváty $x chemická syntéza $x farmakologie $7 D012236
650    _2
$a Spinacia oleracea $x účinky léků $x metabolismus $7 D018724
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Dolezel, Jan
700    1_
$a Kralova, Katarina
700    1_
$a Pesko, Matus
700    1_
$a Kunes, Jiri
700    1_
$a Jampílek, Josef $7 xx0027075
773    0_
$w MED00180394 $t Molecules (Basel, Switzerland) $x 1420-3049 $g Roč. 16, č. 6 (20110622), s. 5207-27
856    41
$u https://pubmed.ncbi.nlm.nih.gov/21697777 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m
990    __
$a 20120817 $b ABA008
991    __
$a 20130325064213 $b ABA008
999    __
$a ok $b bmc $g 949529 $s 784833
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2011 $b 16 $c 6 $d 5207-27 $e 20110622 $i 1420-3049 $m Molecules $n Molecules $x MED00180394
LZP    __
$a Pubmed-20120817/11/03

Najít záznam

Citační ukazatele

Možnosti archivace