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Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: an unexpected prognostic significance?
L. Kren, O. Slaby, K. Muckova, E. Lzicarova, M. Sova, V. Vybihal, T. Svoboda, P. Fadrus, R. Lakomy, P. Vanhara, Z. Krenova, J. Sterba, M. Smrcka, J. Michalek,
Language English Country Australia
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NS9875
MZ0
CEP Register
NS9871
MZ0
CEP Register
Digital library NLK
Full text - Article
Full text - Article
Source
Source
NLK
Medline Complete (EBSCOhost)
from 1998-03-01 to 1 year ago
Wiley Online Library (archiv)
from 1997-01-01 to 2012-12-31
- MeSH
- Tissue Array Analysis MeSH
- Glioblastoma metabolism mortality pathology MeSH
- HLA Antigens biosynthesis MeSH
- HLA-G Antigens MeSH
- Immunohistochemistry MeSH
- Humans MeSH
- Histocompatibility Antigens Class I biosynthesis MeSH
- Biomarkers, Tumor analysis MeSH
- Cell Line, Tumor MeSH
- Brain Neoplasms metabolism mortality pathology MeSH
- Prognosis MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The role of nonclassical human leukocyte antigens G and E (HLA-G and HLA-E) was originally thought to be restricted to the protection of the fetus from a maternal allorecognition. Now it is known that HLA-G and HLA-E exert multiple immunoregulatory functions. A prognostic significance of the expression of HLA-G and HLA-E by neoplastic cells in glioblastoma is not well characterized. In this study, we evaluated the expression of HLA-G and HLA-E by neoplastic cells in 39 cases of glioblastoma. We found the production of HLA-G and HLA in a majority of cases. There was an unexpected positive correlation between the expression of HLA-E and length of survival. We speculate that the expression of this molecule by neoplastic cells may represent a coincidental selective pro-host advantage related to better response to subsequent therapeutic modalities. Mechanisms of glioblastoma cell pathophysiology and mechanisms of responses to therapeutic interventions in respect to the expression of these molecules deserves further study.
References provided by Crossref.org
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