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Acute toxicity of surfactants and detergent-based decontaminants in mice and rats
Jan Misik, Eva Vodakova, Ruzena Pavliákova, Jiri Cabal, Ladislav Novotny, Kamil Kuca
Language English Country Czech Republic
Document type Research Support, Non-U.S. Gov't
Digital library NLK
Source
NLK
ROAD: Directory of Open Access Scholarly Resources
from 2011
- Keywords
- Argos(TM), FloraFree(TM), Dermogel(TM), Neodekont(TM), althosan MB, triton X, sodium alkylbenzene sulphonate,
- MeSH
- Administration, Cutaneous MeSH
- Administration, Oral MeSH
- Decontamination MeSH
- Detergents * toxicity MeSH
- Histological Techniques MeSH
- Injections, Intramuscular MeSH
- Lethal Dose 50 MeSH
- Models, Animal * MeSH
- Mice, Inbred ICR MeSH
- Rats, Wistar MeSH
- Surface-Active Agents toxicity MeSH
- Toxicity Tests, Acute * methods statistics & numerical data MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Detergent-based mixtures and pure surfactants used as decontaminants in mass casualty scenarios were investigated for their acute 24 h toxicity. Commercial detergents NeodekontTM, ArgosTM, DermogelTM, and FloraFreeTM were tested in male Wistar rats after percutaneous, peroral and intramuscular administration. Pure surfactants althosan MB, sodium alkylbenzene sulphonate, triton X, benzyl dimethyl dodecyl ammonium chloride, and N-dodecyl pyridinium bromide were investigated in male ICR mice. Estimated LD50 of surfactants varied from < 100 mg.kg-1 (i.m.) to more than 2000 mg.kg-1 (p.o, p.c.) in mice. All detergents tested in rats were rather less toxic (LD50 > 6 ml.kg-1), thus could be considered as safe if used as external skin decontaminant or if low volume is accidentally ingested.
Biomedical Research Center university Hospital Hradec Kralove
Faculty of Military Health Sciences University of Defence Hradec Kralove
Faculty of Veterinary Medicine University of Veterinary and Pharmaceutical Sciences Brno
References provided by Crossref.org
Literatura
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