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Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture
T. Barta, D. Dolezalova, Z. Holubcova, A. Hampl,
Language English Country England, Great Britain
Document type Journal Article, Review
- MeSH
- Cell Differentiation MeSH
- Cell Culture Techniques MeSH
- Cell Cycle physiology MeSH
- Embryonic Stem Cells cytology physiology MeSH
- Cell Cycle Checkpoints physiology MeSH
- Humans MeSH
- Pluripotent Stem Cells cytology physiology MeSH
- Cell Cycle Proteins metabolism physiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules.
References provided by Crossref.org
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- $a Barta, Tomas $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 3, Brno 62500, Czech Republic. serrano@biology.rutgers.edu
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- $a Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules.
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