Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration

M. Kaucká, K. Plevová, S. Pavlová, P. Janovská, A. Mishra, J. Verner, J. Procházková, P. Krejcí, J. Kotasková, P. Ovesná, B. Tichy, Y. Brychtová, M. Doubek, A. Kozubík, J. Mayer, S. Pospísilová, V. Bryja,

. 2013 ; 73 (5) : 1491-1501.

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc13024011

Grant support
NT11217 MZ0 CEP Register
NT13493 MZ0 CEP Register

The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-ε are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13024011
003      
CZ-PrNML
005      
20240109123014.0
007      
ta
008      
130703s2013 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1158/0008-5472.CAN-12-1752 $2 doi
035    __
$a (PubMed)23338609
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Kaucká, Markéta $u Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic $7 _AN068807
245    14
$a The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration / $c M. Kaucká, K. Plevová, S. Pavlová, P. Janovská, A. Mishra, J. Verner, J. Procházková, P. Krejcí, J. Kotasková, P. Ovesná, B. Tichy, Y. Brychtová, M. Doubek, A. Kozubík, J. Mayer, S. Pospísilová, V. Bryja,
520    9_
$a The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-ε are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment.
650    _2
$a zvířata $7 D000818
650    _2
$a B-lymfocyty $x patologie $7 D001402
650    12
$a pohyb buněk $7 D002465
650    12
$a polarita buněk $7 D016764
650    _2
$a lidé $7 D006801
650    _2
$a chronická lymfatická leukemie $x metabolismus $x patologie $7 D015451
650    _2
$a membránové proteiny $x metabolismus $7 D008565
650    _2
$a myši $7 D051379
650    _2
$a signální transdukce $7 D015398
650    _2
$a transplantace heterologní $7 D014183
650    _2
$a upregulace $7 D015854
650    _2
$a signální dráha Wnt $7 D060449
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Plevová, Karla $7 xx0158852 $u CEITEC - Central European Institute of Technology; Center of Molecular Biology and Gene Therapy, Department of Internal Medicine-Hematology and Oncology University Hospital Brno Medical Faculty MU
700    1_
$a Pavlová, Šárka $7 xx0117816 $u CEITEC - Central European Institute of Technology; Center of Molecular Biology and Gene Therapy, Department of Internal Medicine-Hematology and Oncology University Hospital Brno Medical Faculty MU
700    1_
$a Janovská, Pavlína $7 mub20211103818 $u Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
700    1_
$a Mishra, Archana $u Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
700    1_
$a Verner, Jan $7 _BN005953 $u CEITEC - Central European Institute of Technology; Center of Molecular Biology and Gene Therapy, Department of Internal Medicine-Hematology and Oncology University Hospital Brno Medical Faculty MU
700    1_
$a Medalová, Jiřina $7 xx0102053 $u Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
700    1_
$a Krejčí, Pavel $7 xx0007657 $u Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic; Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno
700    1_
$a Kotašková, Jana $7 xx0128614 $u CEITEC - Central European Institute of Technology; Center of Molecular Biology and Gene Therapy, Department of Internal Medicine-Hematology and Oncology University Hospital Brno Medical Faculty MU
700    1_
$a Ovesná, Petra, $d 1982- $7 mub2013761100 $u Institute of Biostatistics and Analyses, masaryk University
700    1_
$a Tichý, Boris $7 xx0312236 $u CEITEC - Central European Institute of Technology; Center of Molecular Biology and Gene Therapy, Department of Internal Medicine-Hematology and Oncology University Hospital Brno Medical Faculty MU
700    1_
$a Brychtová, Yvona $7 xx0105542 $u Center of Molecular Biology and Gene Therapy, Department of Internal Medicine-Hematology and Oncology University Hospital Brno Medical Faculty MU
700    1_
$a Doubek, Michael, $d 1972- $7 mzk2004217554 $u CEITEC - Central European Institute of Technology; Center of Molecular Biology and Gene Therapy, Department of Internal Medicine-Hematology and Oncology University Hospital Brno Medical Faculty MU
700    1_
$a Kozubík, Alois, $d 1958- $7 mzk2004237023 $u Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic; Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno
700    1_
$a Mayer, Jiří, $d 1960- $7 nlk20000083651 $u Center of Molecular Biology and Gene Therapy, Department of Internal Medicine-Hematology and Oncology University Hospital Brno Medical Faculty MU
700    1_
$a Pospíšilová, Šárka, $d 1969- $7 xx0101843 $u CEITEC - Central European Institute of Technology; Center of Molecular Biology and Gene Therapy, Department of Internal Medicine-Hematology and Oncology University Hospital Brno Medical Faculty MU
700    1_
$a Bryja, Vítězslav, $d 1977- $7 xx0035073 $u Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic; Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno
773    0_
$w MED00009437 $t Cancer research $x 1538-7445 $g Roč. 73, č. 5 (2013), s. 1491-1501
856    41
$u https://pubmed.ncbi.nlm.nih.gov/23338609 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20130703 $b ABA008
991    __
$a 20240109123011 $b ABA008
999    __
$a ok $b bmc $g 987691 $s 822391
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2013 $b 73 $c 5 $d 1491-1501 $i 1538-7445 $m Cancer research $n Cancer Res $x MED00009437
GRA    __
$a NT11217 $p MZ0
GRA    __
$a NT13493 $p MZ0
LZP    __
$a Pubmed-20130703

Find record

Citation metrics

Archiving options