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The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration

M. Kaucká, K. Plevová, S. Pavlová, P. Janovská, A. Mishra, J. Verner, J. Procházková, P. Krejcí, J. Kotasková, P. Ovesná, B. Tichy, Y. Brychtová, M. Doubek, A. Kozubík, J. Mayer, S. Pospísilová, V. Bryja,

. 2013 ; 73 (5) : 1491-1501.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc13024011

Grantová podpora
NT11217 MZ0 CEP - Centrální evidence projektů
NT13493 MZ0 CEP - Centrální evidence projektů

The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-ε are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment.

Citace poskytuje Crossref.org

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