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Localization of c-MYB in differentiated cells during postnatal molar and alveolar bone development
V. Lungova, M. Buchtova, E. Janeckova, AS. Tucker, L. Knopfova, J. Smarda, E. Matalova,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- ameloblasty metabolismus MeSH
- buněčná diferenciace genetika MeSH
- buňky pojivové tkáně metabolismus MeSH
- geny myc genetika MeSH
- koncové značení zlomů DNA in situ MeSH
- moláry cytologie růst a vývoj metabolismus MeSH
- myši MeSH
- odontogeneze genetika MeSH
- processus alveolaris cytologie růst a vývoj metabolismus MeSH
- protoonkogenní proteiny c-myb * analýza genetika metabolismus MeSH
- vývoj kostí genetika fyziologie MeSH
- vývojová regulace genové exprese genetika fyziologie MeSH
- zubní cement (tkáň) metabolismus MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The MYB family of transcription activators has been associated with a high proliferation rate and an undifferentiated state of cells in a number of tissues. Recently emerging data suggest that these molecules may also play a role in differentiation. In this study, the pattern of expression of c-MYB was followed during postnatal stages of mouse molar odontogenesis using immunohistochemistry on serial sections. Along with an abundance of the c-MYB protein in proliferating zones, we confirmed the presence of this protein in differentiated ameloblasts, odontoblasts, and osteoblasts. In addition, c-MYB was also found in cementoblasts and alveolar fibroblasts. These findings suggest integration of c-MYB into regulatory networks during hard-tissue differentiation and mineralization.
Citace poskytuje Crossref.org
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- $a The MYB family of transcription activators has been associated with a high proliferation rate and an undifferentiated state of cells in a number of tissues. Recently emerging data suggest that these molecules may also play a role in differentiation. In this study, the pattern of expression of c-MYB was followed during postnatal stages of mouse molar odontogenesis using immunohistochemistry on serial sections. Along with an abundance of the c-MYB protein in proliferating zones, we confirmed the presence of this protein in differentiated ameloblasts, odontoblasts, and osteoblasts. In addition, c-MYB was also found in cementoblasts and alveolar fibroblasts. These findings suggest integration of c-MYB into regulatory networks during hard-tissue differentiation and mineralization.
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