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Localization of c-MYB in differentiated cells during postnatal molar and alveolar bone development
V. Lungova, M. Buchtova, E. Janeckova, AS. Tucker, L. Knopfova, J. Smarda, E. Matalova,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Ameloblasts metabolism MeSH
- Cell Differentiation genetics MeSH
- Connective Tissue Cells metabolism MeSH
- Genes, myc genetics MeSH
- In Situ Nick-End Labeling MeSH
- Molar cytology growth & development metabolism MeSH
- Mice MeSH
- Odontogenesis genetics MeSH
- Alveolar Process cytology growth & development metabolism MeSH
- Proto-Oncogene Proteins c-myb * analysis genetics metabolism MeSH
- Bone Development genetics physiology MeSH
- Gene Expression Regulation, Developmental genetics physiology MeSH
- Dental Cementum metabolism MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The MYB family of transcription activators has been associated with a high proliferation rate and an undifferentiated state of cells in a number of tissues. Recently emerging data suggest that these molecules may also play a role in differentiation. In this study, the pattern of expression of c-MYB was followed during postnatal stages of mouse molar odontogenesis using immunohistochemistry on serial sections. Along with an abundance of the c-MYB protein in proliferating zones, we confirmed the presence of this protein in differentiated ameloblasts, odontoblasts, and osteoblasts. In addition, c-MYB was also found in cementoblasts and alveolar fibroblasts. These findings suggest integration of c-MYB into regulatory networks during hard-tissue differentiation and mineralization.
References provided by Crossref.org
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