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Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus)

K Bender, RT Seibert, TF Wienker, V Kren, M Pravenec, S Bissbort

. 1994 ; 32 (5-6) : 147-154.

Language English Country United States

Document type Comparative Study, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc13029424

Grant support
PL548 MZ0 CEP Register

A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fixed either allele Mgd1a or allele Mgd1b. Codominant expression is observed in heterozygotes, providing evidence for a tetrameric enzyme structure. Backcross progenies showed the expected 1:1 segregation ratio, and there is evidence that Mgd1 is linked to Pep3 and Fh1 on chromosome 13. There is also evidence for two additional methylglyoxal dehydrogenases: Mgd2, present in liver and kidney, and Mgd3, present only in heart.

Bibliography, etc.

Literatura

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$a A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fixed either allele Mgd1a or allele Mgd1b. Codominant expression is observed in heterozygotes, providing evidence for a tetrameric enzyme structure. Backcross progenies showed the expected 1:1 segregation ratio, and there is evidence that Mgd1 is linked to Pep3 and Fh1 on chromosome 13. There is also evidence for two additional methylglyoxal dehydrogenases: Mgd2, present in liver and kidney, and Mgd3, present only in heart.
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$a Seibert, R. T. $u Institut fur Humangenetik und Anthropologie, Universitat Freiburg, Germany
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$a Wienker, T. F. $u Institut fur Humangenetik und Anthropologie, Universitat Freiburg, Germany
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