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Absorption, metabolism and elimination of N,N-dimethylformamide in humans
J Mraz, H Nohova
Language English Country Germany
Grant support
IZ265
MZ0
CEP Register
PubMed
1399028
DOI
10.1007/bf00381474
Knihovny.cz E-resources
- MeSH
- Absorption MeSH
- Acetylcysteine analogs & derivatives urine MeSH
- Dimethylformamide analogs & derivatives pharmacokinetics metabolism MeSH
- Adult MeSH
- Formamides metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Lung physiology metabolism MeSH
- Solvents pharmacokinetics metabolism MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
Excretion of N,N-dimethylformamide (DMF) and DMF metabolites N-hydroxymethyl-N-methylformamide ("MF"), N-hydroxymethyl-formamide ("F") and N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC) has been monitored in the urine of volunteers during and after their 8-h exposure to DMF vapour at a concentration of 10, 30 and 60 mg.m-3. The pulmonary ventilation in these experiments was typically about 10 l.min-1 and the retention in the respiratory tract was 90%. After exposure to 30mg DMF.m-3, the yield of compound determined in the urine represented 0.3% (DMF), 22.3% ("MF"), 13.2% ("F") and 13.4% (AMCC) of the dose absorbed via the respiratory tract. The excretion curves of the particular compounds attained their maximum 6-8h (DMF), 6-8h ("MF"), 8-14h ("F") and 24-34h (AMCC) after the start of the exposure. The half-times of excretion were approximately 2, 4, 7 and 23 h respectively. In contrast to slow elimination of AMCC after exposure to DMF, AMCC was eliminated rapidly after AMCC intake. This discrepancy could be explained by rate-limiting reversible protein binding of a reactive metabolic intermediate of DMF, possibly methylisocyanate.
References provided by Crossref.org
Literatura
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