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Comparison of functional fibrinogen assessment using thromboelastography with the standard von Clauss method

I. Fluger, K. Maderova, M. Simek, R. Hajek, J. Zapletalova, V. Lonsky

. 2012 ; 156 (3) : 260-261.

Language English Country Czech Republic

Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc13039575

Grant support
NS9614 MZ0 CEP Register

AIM: To compare assessment of fibrinogen by thromboelastography with the standard von Clauss method. METHODS: Observational prospective study. RESULTS: Thromboelastography provides direct and complex evaluation of the entire coagulation cascade based upon changes in blood viscosity. It affects both platelets and plasma components. New application of this method measures fibrinogen contribution to coagulation as opposed to fibrinogen antigen levels measured by immunoassay. Paired samples from 117 patients before cardiopulmonary bypass were compared. A moderate correlation was found between fibrinogen and functional fibrinogen with a Spearman correlation coefficient of 0.476. CONCLUSION: The functional fibrinogen test is a valid point-of-care method for fibrinogen assay with a moderate correlation to the standard method.

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