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Anticonvulsant action of gabapentin during postnatal development in rats
Pavel Mareš and Renata Haugvicová
Language English Country United States
Document type Research Support, Non-U.S. Gov't
Grant support
IZ2668
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
NLK
Free Medical Journals
from 1997 to 1 year ago
Wiley Online Library (archiv)
from 1997-01-01 to 2012-12-31
Wiley Free Content
from 1997
- MeSH
- Acetates * pharmacology MeSH
- Amines * MeSH
- Anticonvulsants * pharmacology MeSH
- Behavior, Animal physiology drug effects MeSH
- Epilepsy, Generalized chemically induced prevention & control MeSH
- Epilepsy, Tonic-Clonic chemically induced prevention & control MeSH
- gamma-Aminobutyric Acid * MeSH
- Rats MeSH
- Cyclohexanecarboxylic Acids * MeSH
- Brain growth & development drug effects MeSH
- Pentylenetetrazole * MeSH
- Rats, Wistar MeSH
- Dose-Response Relationship, Drug MeSH
- Seizures * chemically induced prevention & control MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
PURPOSE: To study the anticonvulsant effects of gabapentin (GBP) in immature animals. METHODS: Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizures [minimal (i.e., clonic)] and generalized tonic-clonic (GTCS) were recorded, and seizure severity was scored. RESULTS: GBP suppressed or at least restricted the tonic phase of GTCS at all the developmental stages studied. In addition, minimal seizures were suppressed in 18-day-old rats. Both effects exhibited a tendency to a U-shaped dose-response curve. CONCLUSIONS: Anticonvulsant effects of GBP were demonstrated in immature and in adult rats.
References provided by Crossref.org
Literatura
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