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Genetics of anti-EHV antibody responses in a horse population
J. Rusek, M. Klumplerova, D. Molinkova, M. Sedlinska, L. Dusek, J. Muzik, L. Putnova, I. Vrtkova, V. Celer, P. Horin,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Odkazy
PubMed
23582518
DOI
10.1016/j.rvsc.2013.03.011
Knihovny.cz E-zdroje
- MeSH
- fenotyp MeSH
- genotyp MeSH
- herpesvirus 1 koní genetika imunologie MeSH
- herpetické infekce genetika imunologie veterinární virologie MeSH
- jednonukleotidový polymorfismus genetika MeSH
- koně MeSH
- mikrosatelitní repetice MeSH
- nemoci koní genetika imunologie virologie MeSH
- neparametrická statistika MeSH
- polymerázová řetězová reakce veterinární MeSH
- protilátky virové krev MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p<0.001) in antibody titers between two color varieties of Old Kladruber horses, separate association studies were performed in the two sub-populations by using the Fisher's exact test. In black horses, the interleukin 4 receptor and MxA protein coding genes, and the microsatellite TKY325 were associated with the responder status. In the grey population, the microsatellite TKY343 showed significant association with anti-EHV antibody responsiveness after Bonferroni corrections.
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