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Combined measurement of plasma cell proliferative and apoptotic index in multiple myeloma defines patients with good and poor prognosis

Jiri Minarik, Vlastimil Scudla, Marta Ordeltova, Tomas Pika, Jaroslav Bacovsky, Michael Steinbach, Vipin Kumar, Brian Van Ness

. 2011 ; 35 (1) : 44-48.

Language English Country England, Great Britain

Document type Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc14055245

Grant support
NR9489 MZ0 CEP Register
NR9500 MZ0 CEP Register

We assessed plasma cell proliferation (by propidium iodide index, PC-PI) and apoptosis (by annexin-V index PC-AI) for the estimation of overall survival (OS) in multiple myeloma (MM) patients. 181 patients with newly diagnosed MM were assessed, treated using conventional chemotherapy. The values best discriminating patients with poor prognosis were PC-PI>3.0% and PC-AI<4.75%, and for good prognosis PC-PI<3.0% and PC-AI>4.75%. The median OS was 8 months vs 40 months, p=0.0002. Our results suggest that combined measurement of plasma cell proliferation and apoptosis creates a unique strong prognostic factor based on growth characteristics of the tumor clone. Copyright 2010 Elsevier Ltd. All rights reserved.

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$a Ščudla, Vlastimil, $d 1946- $7 jn20000402953 $u Department of Internal Medicine III, University Hospital Olomouc, Olomouc, Czech Republic
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$a Ordeltová, Marta $7 xx0100431 $u Department of Immunology, University Hospital Olomouc, Olomouc, Czech Republic
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$a Steinbach, Michael $u Department of Computer Science and Engineering, University of Minnesoty, United States
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$a Kumar, Vipin $u Department of Computer Science and Engineering, University of Minnesoty, United States
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