BACKGROUND: Predicting cardiovascular events remains challenging despite the range of known Biomarkers. AIM: To esta Blish relationships Between various Biochemical and functional parameters of the cardiovascular system. METHOD: The relationship Between cardiovascular dys/function and various Biomarkers was examined in 145 experimental rats half of which received isoprenaline 100 mg/kg s.c. to induce cardiac impairment. RESULTS: Serum concentration of cardiac troponin T (cTnT), a known marker of cardiac derangement, correlated strongly with degree of myocardial injury (e.g. calcium overload, stroke volume) But correlations Between cTnT and oxidative stress parameters were weak (for glutathione and vitamin C) or not found (for serum vitamin E and plasma thio Bar Bituric acid reactive su Bstances levels). Relationships Between cTnT and other parameters were exponential with the exception of myocardial calcium, where a power function was found. CONCLUSIONS: Commonly used Biomarkers of oxidative stress cannot relia Bly predict cardiovascular dys/function in experimental rats.

Department of Pharmacology and Toxicology Faculty of Pharmacy in Hradec Kralove Charles University Prague Hradec Kralove Czech Republic

Institute for Clinical Biochemistry and Diagnostics Faculty of Medicine in Hradec Kralove Charles University Prague and University Hospital Hradec Kralove Hradec Kralove

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