Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Erythropoiesis- and thrombopoiesis-characterizing parameters in adenosine A3 receptor knock-out mice

M. Hofer, M. Pospíšil, L. Dušek, Z. Hoferová, L. Weiterová, D. Komůrková

. 2013 ; 62 (3) : 305-311.

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc14056873

Influence of the regulatory system mediated by adenosine A(3) receptors on the functioning of erythropoiesis and thrombopoiesis was studied by means of evaluation of the numbers and attributes of peripheral blood erythrocytes and platelets, as well as of erythroid bone marrow progenitor cells in adenosine A(3) receptor knock-out (Adora3(tm1Jbsn)/Adora3(tm1Jbsn), A(3)AR((-/-))) mice and their wild-type C57BL/6 counterparts, both males and females. Minor but statistically significant disturbances in the properties of erythrocytes, namely in the parameters of mean erythrocyte volume and mean erythrocyte hemoglobin were observed in A(3)AR((-/-)) mice. In addition, adenosine A(3) receptor knock-out mice were found to exhibit an expressive, statistically significant decrease of their blood platelet count, amounting to 17 % and 21 % in males and females, respectively. This decrease in platelet levels was accompanied by a significant 17 % decline in the plateletcrit in both sexes. The obtained data can help to define therapeutic applications based on the principle of adenosine receptor signaling.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc14056873
003      
CZ-PrNML
005      
20200714130614.0
007      
ta
008      
140425s2013 xr a f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.932489 $2 doi
035    __
$a (PubMed)23489188
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Hofer, Michal $7 xx0074123 $u Laboratory of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Brno, Czech Republic
245    10
$a Erythropoiesis- and thrombopoiesis-characterizing parameters in adenosine A3 receptor knock-out mice / $c M. Hofer, M. Pospíšil, L. Dušek, Z. Hoferová, L. Weiterová, D. Komůrková
520    9_
$a Influence of the regulatory system mediated by adenosine A(3) receptors on the functioning of erythropoiesis and thrombopoiesis was studied by means of evaluation of the numbers and attributes of peripheral blood erythrocytes and platelets, as well as of erythroid bone marrow progenitor cells in adenosine A(3) receptor knock-out (Adora3(tm1Jbsn)/Adora3(tm1Jbsn), A(3)AR((-/-))) mice and their wild-type C57BL/6 counterparts, both males and females. Minor but statistically significant disturbances in the properties of erythrocytes, namely in the parameters of mean erythrocyte volume and mean erythrocyte hemoglobin were observed in A(3)AR((-/-)) mice. In addition, adenosine A(3) receptor knock-out mice were found to exhibit an expressive, statistically significant decrease of their blood platelet count, amounting to 17 % and 21 % in males and females, respectively. This decrease in platelet levels was accompanied by a significant 17 % decline in the plateletcrit in both sexes. The obtained data can help to define therapeutic applications based on the principle of adenosine receptor signaling.
650    _2
$a zvířata $7 D000818
650    _2
$a trombocyty $x cytologie $x fyziologie $7 D001792
650    _2
$a erytrocyty $x cytologie $x fyziologie $7 D004912
650    _2
$a erytropoéza $x fyziologie $7 D004920
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a mezenchymální kmenové buňky $x cytologie $x fyziologie $7 D059630
650    _2
$a myši $7 D051379
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a myši knockoutované $7 D018345
650    _2
$a receptor adenosinový A3 $x genetika $x metabolismus $7 D043684
650    _2
$a signální transdukce $x fyziologie $7 D015398
650    _2
$a trombopoéza $x fyziologie $7 D034061
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Pospíšil, Martin $7 _AN051949 $u Laboratory of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Brno, Czech Republic
700    1_
$a Dušek, Ladislav, $d 1967- $7 mzk2003181727 $u Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic
700    1_
$a Hoferová, Zuzana $7 xx0074124 $u Laboratory of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Brno, Czech Republic
700    1_
$a Weiterová, Lenka $7 xx0075192 $u Laboratory of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Brno, Czech Republic
700    1_
$a Komůrková, Denisa $7 _AN075212 $u Laboratory of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Brno, Czech Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 62, č. 3 (2013), s. 305-311
856    41
$u http://www.biomed.cas.cz/physiolres/2013/3_13.htm $y domovská stránka časopisu - plný text volně přístupný = fulltext
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20140425 $b ABA008
991    __
$a 20200714130610 $b ABA008
999    __
$a ok $b bmc $g 1025145 $s 855471
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2013 $b 62 $c 3 $d 305-311 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20140425

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace