-
Je něco špatně v tomto záznamu ?
Spatial reversal learning in chronically sensitized rats and in undrugged sensitized rats with dopamine d2-like receptor agonist quinpirole
H. Hatalova, D. Radostova, A. Pistikova, K. Vales, A. Stuchlik,
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
Grantová podpora
NT13386
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
NLK
Directory of Open Access Journals
od 2007
Free Medical Journals
od 2007
PubMed Central
od 2007
Europe PubMed Central
od 2007
ProQuest Central
od 2007-11-02 do 2021-12-31
Open Access Digital Library
od 2007-01-01
Open Access Digital Library
od 2007-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2007
PubMed
24782730
DOI
10.3389/fnbeh.2014.00122
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
Dopamine plays a role in generating flexible adaptive responses in changing environments. Chronic administration of D2-like agonist quinpirole (QNP) induces behavioral sensitization and stereotypical behaviors reminiscent of obsessive-compulsive disorder (OCD). Some of these symptoms persist even after QNP discontinuation. In QNP-sensitization, perseverative behavior has often been implicated. To test the effect of QNP-sensitization on reversal learning and its association with perseveration we selected an aversively motivated hippocampus-dependent task, active place avoidance on a Carousel. Performance was measured as the number of entrances into a to-be-avoided sector (errors). We tested separately QNP-sensitized rats in QNP-drugged and QNP-undrugged state in acquisition and reversal tasks on the Carousel. In acquisition learning there were no significant differences between groups and their respective controls. In reversal, QNP-sensitized drugged rats showed a robust but transient increase in number of errors compared to controls. QNP-sensitized rats in an undrugged state were not overtly different from the control animals but displayed an altered learning manifested by more errors at the beginning compensated by quicker learning in the second session compared to control animals. Importantly, performance was not associated with perseveration in neither QNP-sensitized drugged nor QNP-sensitized undrugged animals. The present results show that chronic QNP treatment induces robust reversal learning deficit only when the substance is continuously administered, and suggest that QNP animal model of OCD is also feasible model of cognitive alterations in this disorder.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc14064325
- 003
- CZ-PrNML
- 005
- 20181025143205.0
- 007
- ta
- 008
- 140704s2014 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3389/fnbeh.2014.00122 $2 doi
- 035 __
- $a (PubMed)24782730
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Hatalova, Hana $u Institute of Physiology, Academy of Sciences of the Czech Republic , Prague , Czech Republic.
- 245 10
- $a Spatial reversal learning in chronically sensitized rats and in undrugged sensitized rats with dopamine d2-like receptor agonist quinpirole / $c H. Hatalova, D. Radostova, A. Pistikova, K. Vales, A. Stuchlik,
- 520 9_
- $a Dopamine plays a role in generating flexible adaptive responses in changing environments. Chronic administration of D2-like agonist quinpirole (QNP) induces behavioral sensitization and stereotypical behaviors reminiscent of obsessive-compulsive disorder (OCD). Some of these symptoms persist even after QNP discontinuation. In QNP-sensitization, perseverative behavior has often been implicated. To test the effect of QNP-sensitization on reversal learning and its association with perseveration we selected an aversively motivated hippocampus-dependent task, active place avoidance on a Carousel. Performance was measured as the number of entrances into a to-be-avoided sector (errors). We tested separately QNP-sensitized rats in QNP-drugged and QNP-undrugged state in acquisition and reversal tasks on the Carousel. In acquisition learning there were no significant differences between groups and their respective controls. In reversal, QNP-sensitized drugged rats showed a robust but transient increase in number of errors compared to controls. QNP-sensitized rats in an undrugged state were not overtly different from the control animals but displayed an altered learning manifested by more errors at the beginning compensated by quicker learning in the second session compared to control animals. Importantly, performance was not associated with perseveration in neither QNP-sensitized drugged nor QNP-sensitized undrugged animals. The present results show that chronic QNP treatment induces robust reversal learning deficit only when the substance is continuously administered, and suggest that QNP animal model of OCD is also feasible model of cognitive alterations in this disorder.
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Radostova, Dominika $u Institute of Physiology, Academy of Sciences of the Czech Republic , Prague , Czech Republic.
- 700 1_
- $a Pistikova, Adela $u Institute of Physiology, Academy of Sciences of the Czech Republic , Prague , Czech Republic.
- 700 1_
- $a Valeš, Karel $u Institute of Physiology, Academy of Sciences of the Czech Republic , Prague , Czech Republic. $7 xx0070865
- 700 1_
- $a Stuchlík, Aleš, $u Institute of Physiology, Academy of Sciences of the Czech Republic , Prague , Czech Republic. $d 1974- $7 xx0014340
- 773 0_
- $w MED00174541 $t Frontiers in behavioral neuroscience $x 1662-5153 $g Roč. 8, č. - (2014), s. 122
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/24782730 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20140704 $b ABA008
- 991 __
- $a 20181025143714 $b ABA008
- 999 __
- $a ind $b bmc $g 1031809 $s 863057
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2014 $b 8 $c - $d 122 $i 1662-5153 $m Frontiers in behavioral neuroscience $n Front Behav Neurosci $x MED00174541
- GRA __
- $a NT13386 $p MZ0
- LZP __
- $a Pubmed-20140704