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Correlation between genetic and geographic structure in Europe
O Lao, TT Lu, M Nothnagel, O Junge, S Freitag-Wolf, A Caliebe, M Balascakova, J Bertranpetit, LA Bindoff, D Comas, G Holmlund, A Kouvatsi, M Macek, I Mollet, W Parson, J Palo, R Ploski, A Sajantila, A Tagliabracci, U Gether, T Werge, F...
Jazyk angličtina Země Velká Británie
Typ dokumentu práce podpořená grantem
Grantová podpora
NR9448
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
NLK
Cell Press Free Archives
od 1995-01-01 do Před 1 rokem
Free Medical Journals
od 1995 do Před 1 rokem
ScienceDirect (archiv)
od 1993-01-01 do 2008-12-31
- MeSH
- běloši * genetika MeSH
- genotyp MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- populační genetika MeSH
- vazebná nerovnováha MeSH
- zeměpis MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
Understanding the genetic structure of the European population is important, not only from a historical perspective, but also for the appropriate design and interpretation of genetic epidemiological studies. Previous population genetic analyses with autosomal markers in Europe either had a wide geographic but narrow genomic coverage [1, 2], or vice versa [3-6]. We therefore investigated Affymetrix GeneChip 500K genotype data from 2,514 individuals belonging to 23 different subpopulations, widely spread over Europe. Although we found only a low level of genetic differentiation between subpopulations, the existing differences were characterized by a strong continent-wide correlation between geographic and genetic distance. Furthermore, mean heterozygosity was larger, and mean linkage disequilibrium smaller, in southern as compared to northern Europe. Both parameters clearly showed a clinal distribution that provided evidence for a spatial continuity of genetic diversity in Europe. Our comprehensive genetic data are thus compatible with expectations based upon European population history, including the hypotheses of a south-north expansion and/or a larger effective population size in southern than in northern Europe. By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry.
Cologne Center for Genomics and Institut für Genetik University of Cologne Cologne Germany
Department of Epidemiology Erasmus University Medical Center Rotterdam Rotterdam The Netherlands
Department of Forensic Medicine University of Helsinki Helsinki Finland
Department of Medical Genetics Medical University Warsaw Warsaw Poland
Genetics GlaxoSmithKline Research Triangle Park North Carolina
Institut für Medizinische Informatik und Statistik Christian Albrechts University Kiel Kiel Germany
Institut für Medizinische Molekularbioiogie Christian Albrechts University Kiel Kiel Germany
Institute of Legal Medicine Medical University Insbruck Insbruck Austria
Istituto di Medicína Legale University of Ancona Ancona Italy
Laboratoire ďEmpreintes Génétiques EFS RA site de Lyon Lyon France
Unitat de Biologia Evolutiva Pompeu Fabra University Barcelona Catalonia Spain
Citace poskytuje Crossref.org
Literatura
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