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Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach
Jiri Sochor, Lukas Nejdl, Branislav Ruttkay-Nedecky, Andrea Bezdekova, Katerina Lukesova, Ondrej Zitka, Natalia Cernei, Petr Mares, Miroslav Pohanka, Vojtech Adam, Petr Babula, Miroslava Beklova, Ladislav Zeman, Rene Kizek
Journal of Applied Biomedicine.
2014 ;
12 (2) :
97-110.
Language English Country Czech Republic
Document type Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc14065926
- Keywords
- thiol antioxidant,
- MeSH
- Erythrocytes drug effects MeSH
- Glucose analysis MeSH
- Glutathione * drug effects MeSH
- Glutathione Disulfide drug effects MeSH
- Glutathione Peroxidase drug effects MeSH
- Glutathione Reductase drug effects MeSH
- Plasma enzymology chemistry drug effects MeSH
- Rats MeSH
- Uric Acid analysis MeSH
- Metallothionein * drug effects MeSH
- Oxidative Stress drug effects MeSH
- Peroxiredoxins * drug effects MeSH
- Rats, Wistar MeSH
- Statistics as Topic MeSH
- Superoxide Dismutase drug effects MeSH
- Taurine * analysis administration & dosage blood MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Taurine (2-aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues. It is involved in many physiological processes. Thus, it is widely discussed especially due to its antioxidant properties. In this study, we focused on the effect of taurine supplementation on the concentration of antioxidants in blood plasma and erythrocytes of Wistar rats. Taurine was applied in feed mixture in the dosage of 0, 1, 250, 500, 750, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg. We monitored both enzymatic and non-enzymatic antioxidants – glutathione peroxidase, glutathione reductase, and superoxide dismutase and reduced/oxidized glutathione and metallothionein. Using three different methods 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Ferric Reducing Antioxidant Power (FRAP) and free radicals, we determined antioxidant capacity. In addition, we monitored levels of uric acid and glucose. Our results revealed significant changes in both enzymatic and non-enzymatic parameters with the increasing taurine supplementation.
Central European Institute of Technology Brno University of Technology Brno
Department of Chemistry and Biochemistry Faculty of Agronomy Mendel University in Brno Brno
References provided by Crossref.org
Bibliography, etc.
Literatura
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